shMDR1cṲdǼ{˷[ˎо
l(f)rg2020-11-19 17:35
ĿČmi(Cervical cancer)Ŀǰ(ni)DҊĐ[,ӰŮԽ^D(zhun)ԺA(y)(f)l(f)ʸߵcĿǰR϶ȡˎί鱣د,SίL,Oa(chn)ˎ,ҳˎ֏(f)ˎԵķ,ĶЧ@ȞҪmiP-ǵ(P-gp)_ˮƽh,w(ni)P-gpߵČmi߸a(chn)ˎ@pP-ǵ^ȱ_ܳɞ˷miˎP(gun)IMDR1P-gpľa,˰oĬMDR1ЧpP-gp_(Gefitinib),һNƤLwҰἤø(EGFR-TK)Ƅ,R(jng)ίС,S|(zh)ˎCƵо,F(xin)ڼҲV(yng)ڌmiί,ˎF(xin)Įa(chn)˼Ŀ[˱n}MСɔ_RNAshMDR1ˎMoĬ,pP-gpı_,ˎİl(f),ʹͼmiHela«@ÌоO(sh)ӋƂ䚤Ǽ{ԭˎcshMDR1ͬڼ{,F(xin)Ϳ[ˎĹf칲d{ķ(wn)Լ,d{ˎֳӰ,̽shMDR1ͼṲd{zȡCCǰdcshMDR1п˷[ˎĝ|(zh),ӻЧչȷĺy,ľԡ؏(f)(wn)ԺͻʵMпxӽ(lin)cshMDR1dڲϚ,ƂɚǼ{ƂĹd{Mб,^ΑB(ti),ͬr{wጷŶȼLڷ(wn)Mпͨ^zѪ屣oø⌍욤nj|(zh)shMDR1ıoá۽@R^shMDR1cṲd{ڼ(ni)ķֲrͨ^zȡzȡd{ʽd{w⿹[Mп\MTT̽shMDR1cṲd{miֳӰʽg(sh)shMDR1cṲd{ӰWestern blotzyd{P(gun)ı_rY(ji)ļԭˎshMDR1yܶ؏(f)(wn)ԺͻʾϷW(xu)Ҫ,ʜyڼcshMDR1w⺬yYxƂshMDR1cṲd{̎,Ƃļ{С,R^{ΑB(ti)ʾo,ɢʽY(ji)@ʾx̎܉ܺõČ߰ڼ{Сʞ89.8%7.1%,shMDR188.3%7.2%dǼ{ጷųʬF(xin)pHه,pH5.8l¼Ѹጷ,pH7.4lጷž,shMDR1ڼ{еጷОcț]@,48 hrshMDR1ڃɷNpHlµӋጷʾs75%,wF(xin)߾ļ{кܺõጷŵ_Һ۽@R^쵽dǼ{܉܇,ҸОʕrg̈́هzȡ?zi)܉Cd{ĔzȡcW(wng)錧(do)P(gun),ͨ^NƄʾ{ڼ(ni)D(zhun)\هMTTcʽY(ji)@ʾshMDR1cṲd{܉ƌmiֳ,^ļ,܉T(do)@ӵWestern blotY(ji)dǼ{@ӼCleaved caspase-3ı_,ͬrf͵shMDR1܉pMDR1ĺ,Cd{܉D(zhun)MDR1錧(do)ˎCY(ji)ՓоɹƂ˹dshMDR1cĚǼ{,ƂĹd{дС,ΑB(ti),ɢ,pHهጷŵc鱾ĵļ{dw܉Чo|(zh)cˎѪøڭh(hun)±ⱻd{ͼHela@ֳ,CshMDR1M뼚,ˎMDR1ı_,(do)P-gp_p,D(zhun)ˎ,ʹˎHela֏(f),@ڲhδ,{g(sh)(yng)ڻ̰l(f)],(chung)ărֵ
W(xu)λλ\t(y)ƴW(xu)
W(xu)λeTʿ
W(xu)λݡ2018
ЈDR96
ֈDġ
ҊVD
D 1B ҊVD˜L Y(ji)ʾX SǼ˜Ʒ CY SLƳɘ˜õؚw A=0.0212C+0.023
ų䌦Ậyĸɔ_D 1A ҊVDD 1B ҊVD2˜LD 2 Y(ji)ʾX SǼ˜Ʒ CY S A(j)ÙzyY(ji)LƳɘ˜õؚw A=0.0212C+0.023P(gun)ϵ(sh) r0.9991f|(zh) 150 g/mL (ni)P(gun)ϵá
īI
ľ̖2890269
W(xu)λλ\t(y)ƴW(xu)
W(xu)λeTʿ
W(xu)λݡ2018
ЈDR96
ֈDġ
ҊVD
D 1B ҊVD˜L Y(ji)ʾX SǼ˜Ʒ CY SLƳɘ˜õؚw A=0.0212C+0.023
ų䌦Ậyĸɔ_D 1A ҊVDD 1B ҊVD2˜LD 2 Y(ji)ʾX SǼ˜Ʒ CY S A(j)ÙzyY(ji)LƳɘ˜õؚw A=0.0212C+0.023P(gun)ϵ(sh) r0.9991f|(zh) 150 g/mL (ni)P(gun)ϵá
īI
P(gun)ڿՓ ǰ10l
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ľ̖2890269
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