【摘要】：目的：探討原發(fā)性高血壓患者血清25-羥基維生素D[25(OH)D]水平與血壓變異性(BPV)的相關(guān)性,為高血壓的臨床治療提供依據(jù)。方法：連續(xù)性選取2012年6—12月在新疆醫(yī)科大學第一附屬醫(yī)院住院部就診的原發(fā)性高血壓患者140例,所有患者行24 h動態(tài)血壓監(jiān)測并測定血清25(OH)D水平,根據(jù)血清25(OH)D水平分為25(OH)D非缺乏組65例和25(OH)D缺乏組75例,比較兩組患者的血壓水平和BPV,并分析25(OH)D與BPV之間的關(guān)系。結(jié)果：25(OH)D缺乏組的診室收縮壓(cSBP)、診室舒張壓(cDBP)、24 h收縮壓(24hSBP)、24 h舒張壓(24 hDBP)、日間收縮壓(dSBP)、日間舒張壓(dDBP)、夜間收縮壓(nSBP)、夜間舒張壓(nDBP)、24h收縮壓標準差(24 hSSD)、24 h舒張壓標準差(24 hDSD)、日間收縮壓標準差(dSSD)、日間舒張壓標準差(dDSD)、夜間收縮壓標準差(nSSD)、夜間舒張壓標準差(nDSD)均高于25(OH)D非缺乏組,差異均有統(tǒng)計學意義(P0.05)。血清25(OH)D水平與24 hSSD、24 hDSD、dSSD、dDSD呈負相關(guān)(r值分別為-0.483、-0.320、-0.437、-0.301,P0.01)。多元線性回歸分析顯示,25(OH)D對24 hSSD的影響有統(tǒng)計學意義(P0.01)。結(jié)論：原發(fā)性高血壓患者25(OH)D的缺乏可引起B(yǎng)PV的增加。
[Abstract]:Objective: to investigate the correlation between serum 25 hydroxyvitamin D [25 (OH) D] and blood pressure variability (BPV) in patients with essential hypertension. Methods: one hundred and forty patients with essential hypertension who were hospitalized in the first affiliated Hospital of Xinjiang Medical University from June to December 2012 were selected. All patients were monitored for 24 h ambulatory blood pressure (ABBP) and the serum 25 (OH) D level was measured. According to the serum 25 (OH) D level, 65 cases of 25 (OH) D non-deficiency group and 75 cases of 25 (OH) D deficiency group were divided into two groups. The blood pressure and BPV were compared between the two groups, and the relationship between 25 (OH) D and BPV was analyzed. Results diastolic blood pressure (cDBP) in (cSBP), room was 24 h systolic blood pressure (24hSBP) 24 h diastolic blood pressure (24 hSSD) 24 h diastolic blood pressure standard deviation (24 hSSD) (dDBP), night systolic blood pressure (nSBP), night diastolic blood pressure (nDBP) (24 hSSD) 24 h diastolic blood pressure standard deviation (24 hSSD). (24 hDSD), daytime systolic blood pressure standard deviation (dSSD), daytime diastolic pressure standard deviation (dDSD), nocturnal systolic pressure standard deviation (nSSD), night diastolic blood pressure standard deviation (nDSD) were higher than 25 (OH) D group; The difference was statistically significant (P0.05). There was a negative correlation between the serum 25 (OH) D level and the 24 hour SDD DSDN dDSD (r values were -0.483U -0.3207U -0.437U -0.301g P0.01, respectively). Multiple linear regression analysis showed that the effect of 25 (OH) D on 24 hSSD was statistically significant (P0.01). Conclusion: the lack of 25 (OH) D in patients with essential hypertension can induce the increase of BPV.
【學位授予單位】：新疆醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2015
【分類號】：R544.11

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1 李世云;李勤;李強;鄭振;熊萍;茍曉琴;錢少平;;成都市成人維生素D營養(yǎng)狀況[J];中國骨質(zhì)疏松雜志;2012年11期

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