【摘要】：目的探索高血壓患者24h尿鈉鉀比值對同型半胱氨酸(Hcy)水平的影響。方法選取2015年1月—2016年12月在新疆醫(yī)科大學(xué)第一附屬醫(yī)院心血管內(nèi)科住院確診的高血壓患者958例為研究對象。根據(jù)病歷詳細(xì)收集患者一般資料。所有患者按照要求留取24h尿液標(biāo)本,檢測24h尿鉀、尿鈉水平和尿鈉鉀比值,并在同一天抽取血液標(biāo)本檢測血清鈉、血清鉀、Hcy、三酰甘油(TG)、總膽固醇(TC)等指標(biāo)。根據(jù)所有入選患者24h尿鈉鉀比值水平按三分位法將其分為3組:尿鈉鉀比值≤4.05(T1組,n=320);4.06~6.16(T2組,n=319)和6.16(T3組,n=319)。采用多元線性回歸分析探討高血壓患者24h尿鈉鉀比值對Hcy水平的影響。結(jié)果 3組患者24h尿鈉水平為130~260 mmol/24h,中位水平為182.90(107.79)mmol/24h;24h尿鉀水平為25~100 mmol/24h,中位水平為35.73(18.37)mmol/24h;24h尿鈉鉀比值中位水平為4.99(3.33)。3組患者24h尿鈉、尿鉀、尿鈉鉀比值及Hcy水平比較,差異有統(tǒng)計學(xué)意義(P0.05)。多元線性回歸分析結(jié)果顯示,24h尿鈉鉀比值是Hcy的影響因素[b=0.409,95%CI(0.053,0.765),P0.05]�？刂苹颊哐邂c鉀水平、性別、年齡、BMI、血壓等多個混雜因素后,24h尿鈉鉀比值仍是Hcy的影響因素[b=0.461,95%CI(0.063,0.859),P0.05]。結(jié)論高血壓患者24h尿鈉鉀比值是Hcy的影響因素。通過減少鈉攝入、增加鉀攝入等改善不良飲食習(xí)慣是高血壓非藥物治療的重要組成部分,應(yīng)當(dāng)引起廣大高血壓患者及臨床醫(yī)生的重視。
[Abstract]:Objective to investigate the effect of 24 h urinary sodium-potassium ratio on homocysteine (Hcy) level in patients with hypertension. Methods 958 patients with hypertension were selected from January 2015 to December 2016 in the Department of Cardiovascular Medicine of the first affiliated Hospital of Xinjiang Medical University. Collect the patient's general information according to the medical record. 24 hours urine samples were taken from all the patients, and 24 hours urine potassium, urinary sodium level and urinary sodium potassium ratio were measured. The serum sodium, serum potassium cysts, triglyceride (TG), total cholesterol (TC) were collected from blood samples on the same day. According to the 24-hour urinary sodium and potassium ratio, all the patients were divided into three groups according to the three-position method: urinary natriuretic potassium ratio 鈮，

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