發(fā)布時間：2018-09-09 10:41

【摘要】：目的:比較吳茱萸湯顆粒劑、配方顆粒劑與傳統(tǒng)湯劑中指標性成分的含量差異。方法:采用不同高效液相色譜法(HPLC)測定吳茱萸顆粒劑、配方顆粒劑與傳統(tǒng)湯劑中吳茱萸堿、吳茱萸次堿、人參皂苷Re和人參皂苷Rb1的含量,并對含量測定方法進行考察。結果:顆粒劑、配方顆粒劑與傳統(tǒng)湯劑中吳茱萸堿和吳茱萸次堿質量濃度之和分別為47.32,13.49,12.60 mg·L~(-1),顆粒劑、配方顆粒劑中二者的質量濃度之和分別為傳統(tǒng)湯劑的3.76,1.07倍;人參皂苷Re和人參皂苷Rb1質量濃度之和分別為335.23,345.28,307.39 mg·L~(-1)。顆粒劑、配方顆粒劑中二者的質量濃度之和分別為傳統(tǒng)湯劑的1.09,1.12倍。結論:比較吳茱萸堿和吳茱萸次堿的含量時,顆粒劑與傳統(tǒng)湯劑相差較大,而配方顆粒劑與傳統(tǒng)湯劑基本一致;比較人參皂苷Re和人參皂苷Rb1的含量時,顆粒劑、配方顆粒劑與傳統(tǒng)湯劑基本一致。
[Abstract]:Objective: to compare the content of index components in Ruozhouyu decoction granules, prescription granules and traditional decoction. Methods: (HPLC) was used to determine the contents of rutaecarpine, ginsenoside Re and ginsenoside Rb1 in Evodia rutaecarpa granules, formulated granules and traditional decoction. Results: the sum of the mass concentrations of rutaecarpine and rutaecarpine in granules, formulated granules and traditional decoction was 47.32 (13.49) mg / L ~ (-1), respectively, and the sum of the mass concentrations in granules and granules was 3.761.07 times of that of traditional decoction. The sum of ginsenoside Re and ginsenoside Rb1 was 335.23345.28307.39 mg L-1, respectively. The sum of the mass concentration of granule and formula granule was 1.12 times of that of traditional decoction. Conclusion: when comparing the contents of rutaecarpine and rutaecarpine, the difference between granule and traditional decoction is great, while the content of ginsenoside Re and ginsenoside Rb1 is basically the same as that of traditional decoction, the content of ginsenoside Re and ginsenoside Rb1 is the same as that of traditional decoction. The formula granule is basically consistent with the traditional decoction.
【作者單位】： 廣東藥科大學;康美(北京)藥物研究院有限公司;
【基金】：廣東省戰(zhàn)略性新興產業(yè)區(qū)域集聚發(fā)展試點項目(2014793)
【分類號】：O657.72;R286.0
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本文編號：2232145