發(fā)布時(shí)間：2018-02-14 22:21

  本文關(guān)鍵詞： 肝臟 免疫耐受 機(jī)制 內(nèi)分泌 靜脈回流 排斥反應(yīng) 胰腎聯(lián)合移植 模型 術(shù)式 豬　出處：《四川大學(xué)》2005年博士論文　論文類(lèi)型：學(xué)位論文

【摘要】：第一部分:豬胰腎聯(lián)合移植模型的建立 [目的]建立豬胰腎聯(lián)合移植內(nèi)分泌門(mén)脈回流外分泌腸道引流(portal-emeric drainage,PE)和內(nèi)分泌體靜脈回流外分泌腸道引流(systemic-enteric drainage,SE)術(shù)式的模型。 [方法]四川當(dāng)?shù)仉s交第一代長(zhǎng)白豬48例,隨機(jī)分成PE和SE組,每組24例。各組根據(jù)血型相容的原理進(jìn)行配對(duì),分別分成供受體。整塊切取供體胰十二指腸及右腎,保留帶腹腔動(dòng)脈、腸系膜前動(dòng)脈(相當(dāng)于人腸系膜上動(dòng)脈)和右腎動(dòng)脈的腹主動(dòng)脈段。手術(shù)切除受體胰腺制成Ⅰ型糖尿病模型,并完整切除受體右腎以備供體腎原位植入,保留左腎。PE組采用供體的門(mén)靜脈和受體的腸系膜前靜脈(相當(dāng)于人腸系膜上靜脈)或門(mén)靜脈行端側(cè)吻合,SE組將供體的門(mén)靜脈和受體的肝后后腔靜脈(相當(dāng)于人肝下下腔靜脈)行端側(cè)吻合。供體的腹主動(dòng)脈段與受體的腹主動(dòng)脈段端側(cè)吻合;右腎靜脈和受體的右腎靜脈端端吻合;移植胰腺胰管和移植腎臟輸尿管分別置引流管,將胰液和尿液引出腹腔。供體十二指腸和受體空腸行端側(cè)吻合。于術(shù)前1d、切胰后30min、關(guān)腹前、術(shù)后1～7d
[Abstract]:The first part: the establishment of the model of porcine pancreas kidney transplantation. [objective] to establish a model of portal-emeric drainagePEand systemic-enteric drainageSEfor combined transplantation of porcine pancreas and kidney. [methods] Forty-eight local crossbred Landrace pigs in Sichuan were randomly divided into PE and SE groups with 24 cases in each group. Each group was matched according to the principle of blood type compatibility and divided into donor receptors. The donor pancreaticoduodenum and right kidney were cut off. The abdominal aorta segment with celiac artery, anterior mesenteric artery (equivalent to superior mesenteric artery) and right renal artery were preserved. The donor portal vein and recipient's anterior mesenteric vein (equivalent to the superior mesenteric vein) or portal vein end-to-side anastomosis of portal vein were used to preserve the left kidney. PE group used the donor portal vein and the recipient's posterior retrohepatic vena cava (equivalent to human liver). End to side anastomosis of inferior inferior vena cava (IVC), end-to-side anastomosis of donor aorta segment and recipient segment of abdominal aorta; The right renal vein was end-to-end anastomosed with the recipient's right renal vein. The donor duodenum and the recipient jejunum were end-to-side anastomosed. 1 day before operation, 30 minutes after pancreatic excision, before abdominal closure, 1 day after operation, 7 days after operation.
【學(xué)位授予單位】：四川大學(xué)
【學(xué)位級(jí)別】：博士
【學(xué)位授予年份】：2005
【分類(lèi)號(hào)】：R-332

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