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急性壞死型胰腺炎在外科學(xué) 分類中的翻譯結(jié)果

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本文關(guān)鍵詞：大鼠急性壞死型胰腺炎病理特征評(píng)定方法的研究，由筆耕文化傳播整理發(fā)布。

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急性壞死型胰腺炎在外科學(xué) 分類中的翻譯結(jié)果

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Pathological Characteristics of Acute Necrotizing Pancreatitis in Rats and the Methods of Evaluation

大鼠急性壞死型胰腺炎病理特征評(píng)定方法的研究

短句來(lái)源

Role of apoptosis in the cell death of rat intestinal epithelium during the early stage of acute necrotizing pancreatitis

細(xì)胞凋亡在急性壞死型胰腺炎早期腸黏膜上皮細(xì)胞死亡中的作用

短句來(lái)源

Effects of glutamine on the intestinal failure in rats model of acute necrotizing pancreatitis

谷氨酰胺對(duì)急性壞死型胰腺炎大鼠腸道衰竭的治療作用

短句來(lái)源

Protective effects of ulinostatin on acute lung injury induced by acute necrotizing pancreatitis in rats

烏司他丁對(duì)急性壞死型胰腺炎大鼠肺損傷的保護(hù)作用

短句來(lái)源

Effect of 5-fluorouracil on Exocrine of Pancreas in Dogs with Acute Necrotizing Pancreatitis

5-氟尿嘧啶對(duì)狗急性壞死型胰腺炎外分泌影響的研究

短句來(lái)源

Comparative analysis of ultrasonography and computerized tomography in the diagnosis of acute necrosis pancreatitis

急性壞死型胰腺炎超聲與CT診斷對(duì)照分析

短句來(lái)源

Objective:To evaluate the diagnostic accuracy of ultrasonograp hy (US)and computerized tomography(CT)on acute necrosis pancreatitis(ANP).

目的評(píng)價(jià)超聲與CT對(duì)急性壞死型胰腺炎(ANP)的診斷價(jià)值。

短句來(lái)源

Pathological Characteristics of Acute Necrotizing Pancreatitis in Rats and the Methods of Evaluation

大鼠急性壞死型胰腺炎病理特征評(píng)定方法的研究

短句來(lái)源

Role of apoptosis in the cell death of rat intestinal epithelium during the early stage of acute necrotizing pancreatitis

細(xì)胞凋亡在急性壞死型胰腺炎早期腸黏膜上皮細(xì)胞死亡中的作用

短句來(lái)源

Effects of glutamine on the intestinal failure in rats model of acute necrotizing pancreatitis

谷氨酰胺對(duì)急性壞死型胰腺炎大鼠腸道衰竭的治療作用

短句來(lái)源

Protective effects of ulinostatin on acute lung injury induced by acute necrotizing pancreatitis in rats

烏司他丁對(duì)急性壞死型胰腺炎大鼠肺損傷的保護(hù)作用

短句來(lái)源

Effect of 5-fluorouracil on Exocrine of Pancreas in Dogs with Acute Necrotizing Pancreatitis

5-氟尿嘧啶對(duì)狗急性壞死型胰腺炎外分泌影響的研究

短句來(lái)源

Experience of the Drainage Tubes' Placement in the Operation of Acute Necrotising Pancreatitis (ANP)

急性壞死型胰腺炎術(shù)中置引流管的探討

短句來(lái)源

Objective:To raise the clinical cure rate of acute necrotising pancreatitis (ANP), and to decrease the interrelated complications of the drainage tube.

目的 :提高急性壞死型胰腺炎 (ANP)臨床治愈率 ,減少引流相關(guān)的并發(fā)癥。

短句來(lái)源

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acute necrotizing pancreatitis

The Penetration of Ciprofloxacin into Human Pancreatic and Peripancreatic Necroses in Acute Necrotizing Pancreatitis

The results showed that acute necrotizing pancreatitis model was induced by injection of 5% sodium taurocholate into the pancreatic duct.

The acute necrotizing pancreatitis model was not induced by injection of E.

Large pharmacological doses of ceruletide administered to conscious dogs by intravenous (i.v.) infusion uniformly induce a severe acute necrotizing pancreatitis within 4 h.

Serum concentrations of free fatty acids (FFA) were assayed in 20 patients with acute necrotizing pancreatitis (ANP).

acute necrotizing pancreatitis

The Penetration of Ciprofloxacin into Human Pancreatic and Peripancreatic Necroses in Acute Necrotizing Pancreatitis

The results showed that acute necrotizing pancreatitis model was induced by injection of 5% sodium taurocholate into the pancreatic duct.

The acute necrotizing pancreatitis model was not induced by injection of E.

Large pharmacological doses of ceruletide administered to conscious dogs by intravenous (i.v.) infusion uniformly induce a severe acute necrotizing pancreatitis within 4 h.

Serum concentrations of free fatty acids (FFA) were assayed in 20 patients with acute necrotizing pancreatitis (ANP).

acute necrotising pancreatitis

Acute necrotising pancreatitis-a role for enterokinase

The management of severe acute necrotising pancreatitis: an evidence-based review of the literature

The investigation of the effects of the celecoxib as a cylooxygenase-2 (COX-2) inhibitor on the course of the acute necrotising pancreatitis (ANP) in rats.

A 17-year-old boy with respiratory failure due to acute necrotising pancreatitis was admitted to our intensive care unit.

He presented with respiratory failure due to acute necrotising pancreatitis that developed five days after he had become ill.

Objective:To investigate the potential role of intestinal microflora barrier in the pathogenesis of pancreatic infection.Methods:Fifteen dogs were colonized with a strain of E.coli JM109 bearing ampicillinresistance plasmid PUC 18.The dogs were divided into two groups.In experimental group (n=8),acute necrotizing pancreatitis(ANP) was induced by injection of 0 5 ml/kg of sodium taurocholate with 3 000 U/kg trypsin into the pancreatic duct.The control group (n=7) underwent laparotomy only.All animals were sacrificed 7 days later.Mucosal and luminal microflora of intestine were analyzed quantitatively,and various organs were harvested for culturing.Results:In the experimental group,population levels of E.coli in the intestine were much higher than those of the controls,while bifidobacterium and lactobacillus were decreased significantly (all P <0 01),resulting in reversal of bifidobacterium/E.coli ratio as compared with the control group ( P <0 05).In addition,intestinal bacteria was isolated from organs of all animals in the experimental group,and JM109 was also detected in most cases.Positive blood culture was 75 0% and 62 5% on day 1 and day 2 after induction of ANP respectively,but no bacteria was found in the controls.Conclusions:This study confirms that microecological disturbance can take place in ANP ,and overgrowth of intestinal gramnegative bacteria may lead to translocation to the pancreas and other organs,becoming the source of pancreatic and peripancreatic infection.

目的：探索腸道生物屏障改變?cè)谝认俑腥局械淖饔�。方法：１５只雜種犬在定植耐氨芐青霉素大腸桿菌（攜帶質(zhì)粒ＰＵＣ１８的ＪＭ１０９）后，隨機(jī)分組。胰腺炎組（８只）胰管內(nèi)注入５％�；悄懰徕c和胰蛋白酶引發(fā)急性壞死型胰腺炎，對(duì)照組（７只）僅作單純剖腹術(shù)，７天后活殺。定量分析腸道粘膜及內(nèi)容物中的菌群數(shù)，且對(duì)血液和內(nèi)臟進(jìn)行細(xì)菌培養(yǎng)。結(jié)果：胰腺炎組腸粘膜及內(nèi)容物中大腸桿菌計(jì)數(shù)均高于對(duì)照組（Ｐ＜０．０５或Ｐ＜０．０１），而雙歧桿菌及乳桿菌均明顯減少（Ｐ均＜０．０１）；腸粘膜厭氧菌／需氧菌比值嚴(yán)重倒置（Ｐ＜０．０５）；臟器和血培養(yǎng)結(jié)果：胰腺炎組所有動(dòng)物均出現(xiàn)了腸道細(xì)菌易位，以腸系膜淋巴結(jié)和胰腺易位率最高（８７．５％～１００．０％），且能找到術(shù)前人工定植于腸道的耐藥質(zhì)粒菌。胰腺炎后第１天和第２天血培養(yǎng)陽(yáng)性率分別為７５．０％和６２．５％，而對(duì)照組全部陰性。結(jié)論：急性壞死型胰腺炎時(shí)腸道出現(xiàn)明顯的細(xì)菌微生態(tài)失調(diào)，以過(guò)度生長(zhǎng)的Ｇ－桿菌為主的腸道細(xì)菌易位到胰腺及其它臟器，成為胰腺及胰周感染的根源。

Objective To investigate whether apoptosis of intestinal epithelial cells occurs at the early stage of acute necrotizing pancreatitis (ANP) in rats. Methods Fourty eight Spraque Dawley rats were used. ANP model of rats was induced by retro injection of 5% sodium taurocholate into biliopancreatic duct. Laparotomized animals without induction of ANP (sham operation) served as controls. The distal segment of ileum specimens were harvested at 3 h, 6 h, 12 h and 24 h after operation and the apoptosis of intestinal epithelial cells was studied by DNA gel electrophoresis, FITC conjugated annexin V and propidium iodide (PI) staining cells analyzed by Flow Cytometry (FCM) and immunohistochemical procedures (TUNEL method). Results The DNA electrophoresis showed that typical “l(fā)adder” patterns appeared at all indicated time points in ANP group, while the DNA specimens from control group presented a single chromosomal lane, except the one at 12 h. Apoptotic percentage of detached intestinal epithelial cells assayed using Annexin V kit by FCM were (53.7±3.7)%, (27.6±6.0)%, (39.0±4.8)%, (29.0±11.3)% at 3 h, 6 h, 12 h and 24 h in control group and (50.3±11.3)%, (79.7±9.2)%, (47.8±17.3)%, (49.6±9.5)% in ANP group. There was a significant difference between two groups at 6 h, P <0.05. The ratio of apoptotic cells and necrotic cells (A/N) was 27.7±17.9. Apoptotic index determined by TUNEL method were significantly increased in ANP group (17.5±3.5, 20.4 ±2.9, 14.8±1.7, 14.2±2.1) compared with control group (6.2±2.4, 7.5±1.7, 10.5±0.9, 5.3 ± 0.8 ) during all observed period, P <0.01, peaked at 6 h. Conclusions It was suggested that apoptosis of intestinal epithelial cells increased at early stage of ANP in rat, especially at 6 h. Apoptosis is a principle model of cell death in rat intestinal epithelium of ANP. These might be involved in the development of intestinal barrier failure during the course of ANP.

目的　觀察急性壞死型胰腺炎 (ANP)大鼠早期腸黏膜上皮細(xì)胞凋亡的發(fā)生及其演變規(guī)律 ,探討其在腸黏膜屏障功能障礙中的作用。方法　Spraque Dawley大鼠 48只 ,采用膽胰管內(nèi)逆行注入5 %牛磺膽酸鈉溶液誘導(dǎo)大鼠ANP模型。假手術(shù)組 (shamoperation ,SO)大鼠僅作剖腹術(shù)。術(shù)后 3、6、12和 2 4h分批處死大鼠 ,取末端回腸組織 ,分別應(yīng)用DNA瓊脂糖凝膠電泳 ,異硫氰基熒光素 (FITC)結(jié)合的Annexin V和碘化丙啶 (PI)標(biāo)記細(xì)胞作流式細(xì)胞儀 (FCM)檢測(cè)和免疫組化 (TUNEL法 )等技術(shù) ,研究ANP大鼠腸黏膜上皮細(xì)胞凋亡。結(jié)果　DNA瓊脂糖凝膠電泳結(jié)果顯示 ,SO組僅于 12h出現(xiàn)“梯形(ladder)”條帶 ;ANP大鼠 ,各時(shí)點(diǎn)均可見(jiàn)“梯形”條帶。FCM檢測(cè)結(jié)果表明 ,術(shù)后 3、6、12和 2 4hSO組腸黏膜上皮脫落細(xì)胞凋亡比例分別為 (5 3 .7± 3 .7) %、(2 7.6± 6 .0 ) %、(39.0± 4.8) %和 (2 9.0± 11.3) % ;ANP組分別為 (5 0 .3± 11.3) %、(79.7± 9.2 ) %、(...

目的　觀察急性壞死型胰腺炎 (ANP)大鼠早期腸黏膜上皮細(xì)胞凋亡的發(fā)生及其演變規(guī)律 ,探討其在腸黏膜屏障功能障礙中的作用。方法　Spraque Dawley大鼠 48只 ,采用膽胰管內(nèi)逆行注入5 %�；悄懰徕c溶液誘導(dǎo)大鼠ANP模型。假手術(shù)組 (shamoperation ,SO)大鼠僅作剖腹術(shù)。術(shù)后 3、6、12和 2 4h分批處死大鼠 ,取末端回腸組織 ,分別應(yīng)用DNA瓊脂糖凝膠電泳 ,異硫氰基熒光素 (FITC)結(jié)合的Annexin V和碘化丙啶 (PI)標(biāo)記細(xì)胞作流式細(xì)胞儀 (FCM)檢測(cè)和免疫組化 (TUNEL法 )等技術(shù) ,研究ANP大鼠腸黏膜上皮細(xì)胞凋亡。結(jié)果　DNA瓊脂糖凝膠電泳結(jié)果顯示 ,SO組僅于 12h出現(xiàn)“梯形(ladder)”條帶 ;ANP大鼠 ,各時(shí)點(diǎn)均可見(jiàn)“梯形”條帶。FCM檢測(cè)結(jié)果表明 ,術(shù)后 3、6、12和 2 4hSO組腸黏膜上皮脫落細(xì)胞凋亡比例分別為 (5 3 .7± 3 .7) %、(2 7.6± 6 .0 ) %、(39.0± 4.8) %和 (2 9.0± 11.3) % ;ANP組分別為 (5 0 .3± 11.3) %、(79.7± 9.2 ) %、(4 7.8± 17.3) %和 (4 9.6± 9.5 ) % ,術(shù)后 6h達(dá)峰值 ,且較SO組明顯增高 (P <0 .0 1) ,凋亡與壞死細(xì)胞 (A/N)比值為 2 7.7± 17.9。TUNEL法顯示 ,凋亡細(xì)胞呈細(xì)胞核固縮、斷片狀 ,術(shù)后 3、6、12和 2 4hSO組凋亡指數(shù)為 6 .2± 2 .4、7.5± 1.7、10 .5± 0 .9和 5 .3± 0 .8;ANP組為 1

Objective To determine the effects of glutamine (Gln) on the intestinal failure in rats with acute necrotizing pancreatitis (ANP) and its possible mechanisms. Methods Fifty-four Spraque-Dawley rats were randomly divided into 3 groups: sham operation (SO, n=18), ANP (n=18), and ANP treated with Gln (ANP+Gln, n=18). ANP model was induced by injection of 5% sodium taurocholate solution into bilo-pancreatic duct. The therapy was continuously given with amino acid solution by a mini-pump via a central intravenous line. In addition, the ANP+Gln group was received 3% Gln dipeptide solution (equal to 2% Gln) with a dosage of 0.5g·kg -1·d -1. These groups were isocaloric and isonitrogenous. Bacterial cultures from pancreas, mesenteric lymph node (MLN), liver, spleen and acites were done at 24, 48, 72 h after operation. Endotoxin level in portal vein was determined. Pathologic changes of intestinal mucosa were also studied. Apoptosis of intestinal mucosa was determined by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) method. Expressions of insulin-like growth factor 1 (IGF-1), Gln synthetase (GSase) and glutaminase (Glnase) mRNA were assayed by reverse transcription polymerase chain reaction (RT-PCR). Results At 24, 48, 72h, the positive rate of bacterial culture and the endotoxin concentration were increased significantly in ANP group compared to the SO group (P<0.05), while Gln could decrease them significantly. Pathologic study showed that the height of mucosal villous in ANP group was lower than that in SO group, indicating the intestinal mucosa became more atrophy. However ,the height of mucosal villous in ANP+Gln group was no significantly difference compared to that in SO group, indicated Gln could preserve the mucosa well. Apoptotic index was increased in ANP group and decreased in Gln treated rats. Expressions of IGF-1, GSase, Glnase mRNA were down-regulated in ANP group, but were up-regulated in ANP+Gln group. Conclusions The intestinal barrier function was impaired in ANP. Gln could protect intestinal barrier function. This action was probably related to its enhancement of IGF-1, GSase and Glnase mRNA expressions and its inhibition of intestinal mucosal apoptosis.

目的　觀察谷氨酰胺 (Gln)對(duì)急性壞死型胰腺炎 (ANP)大鼠腸道衰竭的治療作用 ,并探討其作用機(jī)制。方法　Spraque Dawley大鼠 5 4只 ,隨機(jī)分為假手術(shù)組 (SO)、ANP組、Gln治療組 (ANP +Gln) ,每組 18只。采用 5 %�；悄懰徕c溶液經(jīng)膽胰管內(nèi)逆行注射誘導(dǎo)大鼠ANP模型。大鼠中心靜脈置管 ,用微量輸液泵輸注含等氮、等熱卡的氨基酸溶液 ,ANP +Gln組加入 3%丙氨酸 Gln雙肽 (相當(dāng)于2 %Gln溶液 ,劑量 0 5g·kg-1·d-1)。術(shù)后 2 4、48、72h分批處死大鼠并留取標(biāo)本 ,分別做腸黏膜組織病理檢查 ,肝、胰、脾、腸系膜淋巴結(jié) (MLN)和腹水等組織細(xì)菌培養(yǎng) ,門靜脈血內(nèi)毒素測(cè)定 ,TUNEL法檢測(cè)腸黏膜上皮細(xì)胞凋亡 ;逆轉(zhuǎn)錄聚合酶鏈反應(yīng)研究腸黏膜組織胰島素樣生長(zhǎng)因子 1(IGF 1)、Gln酶和Gln合成酶mRNA表達(dá)。結(jié)果　SO組大鼠各組織培養(yǎng)均無(wú)陽(yáng)性細(xì)菌 ,ANP組細(xì)菌培養(yǎng)陽(yáng)性率明顯高于SO組 ,P <0 0 5 ,以MLN陽(yáng)性率最高 ;ANP +Gln組細(xì)菌培養(yǎng)陽(yáng)性率則顯著低于ANP組 ,P <0 0 5。血漿內(nèi)毒素在A...

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