肝硬化與腸源性內(nèi)毒素血癥關(guān)系的研究進展
發(fā)布時間:2019-01-19 18:30
【摘要】:正肝硬化是一種或多種原因引起的,以肝組織彌漫性纖維化、假小葉和再生結(jié)節(jié)為組織學(xué)特征的進行性慢性肝病,是我國常見疾病和主要死亡病因之一。引起肝硬化的病因很多,我國以病毒性肝炎所致的肝硬化為主,而國外以酒精性肝硬化多見。當機體發(fā)生肝硬化時,由于腸道細菌過度生長、腸道黏膜通透性增高、內(nèi)毒素滅活功能減退等原因?qū)е履c道的細菌及其相關(guān)產(chǎn)物(如內(nèi)毒素)突破腸道屏障,從腸道轉(zhuǎn)移到腸系膜淋巴結(jié)及其他腸外器官,從而
[Abstract]:Positive liver cirrhosis is a progressive chronic liver disease characterized by diffuse fibrosis of liver tissue pseudolobules and regenerative nodules. It is one of the common diseases and major causes of death in China. There are many causes of liver cirrhosis, mainly caused by viral hepatitis in China, while alcoholic cirrhosis is more common in foreign countries. When the body develops cirrhosis, the intestinal bacteria and its related products (such as endotoxin) break through the intestinal barrier due to the excessive growth of intestinal bacteria, the increase of intestinal mucosal permeability and the decrease of endotoxin inactivation function. Metastasis from the intestine to mesenteric lymph nodes and other extraintestinal organs
【作者單位】: 中南大學(xué)湘雅三醫(yī)院;
【分類號】:R575.2
[Abstract]:Positive liver cirrhosis is a progressive chronic liver disease characterized by diffuse fibrosis of liver tissue pseudolobules and regenerative nodules. It is one of the common diseases and major causes of death in China. There are many causes of liver cirrhosis, mainly caused by viral hepatitis in China, while alcoholic cirrhosis is more common in foreign countries. When the body develops cirrhosis, the intestinal bacteria and its related products (such as endotoxin) break through the intestinal barrier due to the excessive growth of intestinal bacteria, the increase of intestinal mucosal permeability and the decrease of endotoxin inactivation function. Metastasis from the intestine to mesenteric lymph nodes and other extraintestinal organs
【作者單位】: 中南大學(xué)湘雅三醫(yī)院;
【分類號】:R575.2
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