發(fā)布時(shí)間：2018-12-11 22:05

【摘要】：幽門(mén)螺桿菌(H.pylori)是一種導(dǎo)致全球近50%人群感染的微需氧菌,是慢性胃炎、消化性潰瘍和胃粘膜相關(guān)淋巴組織淋巴瘤的主要致病因子,并且與胃癌的發(fā)生密切相關(guān),1994年國(guó)際癌癥研究機(jī)構(gòu)將其列為Ⅰ類致癌因子[1]。根除H.pylori可有效地防治其相關(guān)性疾病尤其是胃癌的發(fā)生�，F(xiàn)已明確H.pylori相關(guān)性疾病是一種感染性疾病,它可在人與人之間傳播[2-4],家庭是H.pylori最易傳播的場(chǎng)所,大量研究提示H.pylori感染存在家庭聚集性,與H.pylori根除治療失敗、復(fù)發(fā)和再感染密切相關(guān),并且在反復(fù)治療復(fù)發(fā)與再感染病例過(guò)程中,會(huì)誘導(dǎo)耐藥菌株的產(chǎn)生,增加根除難度。本文就H.pylori感染家庭聚集現(xiàn)象、其產(chǎn)生機(jī)制及如何防治等進(jìn)行一綜述。
[Abstract]:Helicobacter pylori (H.pylori) is a microaerobic bacterium that causes infection in nearly 50% of the world's population. It is the main pathogenic factor of chronic gastritis, peptic ulcer and gastric mucosa-associated lymphoid tissue lymphoma, and is closely related to the occurrence of gastric cancer. In 1994, the International Agency for Research on Cancer (IARC) classified it as a class I carcinogen [1]. Eradication of H.pylori can effectively prevent and treat its associated diseases, especially gastric cancer. It has been established that H.pylori related disease is an infectious disease that can be transmitted from person to person [2-4]. Family is the most easily transmitted site of H.pylori. A large number of studies suggest that H.pylori infection has family aggregation. It is closely related to the failure of H.pylori eradication treatment, recurrence and re-infection, and in the process of repeated treatment of recurrent and re-infection cases, it will induce the production of drug-resistant strains and increase the difficulty of eradication. This article reviews the phenomenon of family aggregation of H.pylori infection, its producing mechanism and how to prevent and cure it.
【學(xué)位授予單位】：南昌大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R573

【參考文獻(xiàn)】

相關(guān)期刊論文 前8條

1 黃梅淑;李俊柳;吳亞;;家庭傳播對(duì)幽門(mén)螺桿菌根除效果的影響[J];河北醫(yī)藥;2012年05期

2 李薇;梁麗芳;;兒童幽門(mén)螺桿菌感染根除失敗及再發(fā)的臨床分析[J];臨床醫(yī)學(xué);2010年07期

3 和燦琳;黃永坤;;幽門(mén)螺桿菌感染的家族聚集性[J];醫(yī)學(xué)綜述;2009年05期

4 黃永坤,戚勤,郝萍,文革生,李海林,周麗芳;彝族兒童幽門(mén)螺桿菌感染HLA-DQA1免疫遺傳學(xué)特征分析[J];臨床兒科雜志;2004年10期

5 王平,陳衛(wèi)星;HLA基因多態(tài)性與幽門(mén)螺桿菌相關(guān)性消化道疾病研究進(jìn)展[J];浙江醫(yī)學(xué);2004年07期

6 陳肖肖,歐弼悠,尚世強(qiáng),吳秀英,章許平,陳黎勤,曲一平;幽門(mén)螺桿菌感染兒童家庭內(nèi)聚集及根除治療相關(guān)性探討[J];中國(guó)實(shí)用兒科雜志;2003年08期

7 高長(zhǎng)明,李忠佑,丁建華,王建東,胡旭,劉體康,徐天亮,李洪川,Fujiyoshi Toshinobu,Takezaki Toshiro,Tajima Kazuo;人類白細(xì)胞抗原DRB1等位基因與幽門(mén)螺桿菌感染的關(guān)系[J];中華流行病學(xué)雜志;2000年06期

8 謝勇,祝金泉,呂農(nóng)華,黃德強(qiáng),張昆和,陳江,王崇文;配偶間幽門(mén)螺桿菌感染的血清流行病學(xué)研究[J];中華消化雜志;1999年03期

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