發(fā)布時間：2018-06-04 23:35

  本文選題：傣醫(yī)藥 + Hp相關(guān)性胃炎��； 參考：《云南中醫(yī)學(xué)院》2016年碩士論文

【摘要】：目的:本課題通過觀察治療前后患者癥狀、Hp感染情況及不良反應(yīng)發(fā)生情況,評價傣藥“雅解沙把”對“麗珠維三聯(lián)”治療Hp相關(guān)性胃炎的增效減毒作用。方法:課題采用臨床開放試驗(yàn)研究,納入符合傣醫(yī)“接崩短皇”診斷標(biāo)準(zhǔn)的Hp相關(guān)性胃炎患者74例,隨機(jī)分為治療組和對照組,治療組36人,對照組38人。對照組服用抗幽門螺桿菌(Hp)常用西藥:麗珠維三聯(lián)(枸櫞酸鉍鉀片+克拉霉素片+替硝唑片),治療組在麗珠維三聯(lián)治療的基礎(chǔ)上加服傣藥“雅解沙把”膠囊。兩組均以10天作為一療程,經(jīng)治療10天后,分別觀察并記錄:(1)兩組患者治療前后的癥狀評分;(2)兩組患者的舌苔變化;(3)兩組患者治療過程中出現(xiàn)的不良反應(yīng);(4)治療組患者治療前后的安全性指標(biāo)。4周后復(fù)查Hp感染情況,觀察兩組患者的Hp根除率。結(jié)果:1.治療10天后治療組的癥狀總積分、胃脘痞滿及大便硬結(jié)難下癥狀積分明顯低于對照組,差異具有統(tǒng)計學(xué)意義(P0.05)。2.治療10天后兩組患者的舌苔分布比較差異具有統(tǒng)計學(xué)意義(P0.05)。3.治療后“接崩短皇”的主要癥狀胃脘部疼痛、消谷善饑、胃中嘈雜、惡心嘔吐的組間比較均無統(tǒng)計學(xué)意義(P0.05)。4.治療組Hp根除率為75.0%,與對照組Hp根除率65.8%比較差異無統(tǒng)計學(xué)意義(P0.05)。5.用藥后治療組的安全性指標(biāo)皆未出現(xiàn)明顯異常。比較兩組治療期間不良反應(yīng)的發(fā)生率(P0.05),差異有統(tǒng)計學(xué)意義。結(jié)論:1.Hp相關(guān)性胃炎患者中“接崩短皇”者男性明顯多于女性。2.與單獨(dú)使用三聯(lián)療法的患者相比聯(lián)合使用雅解沙把的患者,胃脘撐脹及大便硬結(jié)難下的癥狀有更明顯改善,而胃脘部疼痛、消谷善饑、胃中嘈雜、惡心嘔吐等其它主要癥狀兩組間比較則無顯著差異。3.經(jīng)過根除Hp治療后,聯(lián)用“雅解沙把”干預(yù)的患者飄林勒(黃苔)消退效果明顯優(yōu)于單純使用麗珠維三聯(lián)組。說明“雅解沙把”能有效清解體內(nèi)熱邪,防止根除Hp治療過程中的化熱癥狀。4.“雅解沙把”聯(lián)合“麗珠維三聯(lián)”治療“接崩短皇”的Hp根除率為75.0%。5.“雅解沙把”能有效降低三聯(lián)療法的不良反應(yīng)發(fā)生率,臨床應(yīng)用安全有效。
[Abstract]:Objective: to evaluate the synergistic and attenuated effect of Ya Jie Sha Ba (YJB) on the treatment of HP associated gastritis by observing the incidence of HP infection and adverse reactions before and after treatment. Methods: a total of 74 patients with HP associated gastritis were included in the clinical open trial study. They were randomly divided into treatment group (n = 36) and control group (n = 38). The control group took common western medicine of anti-Helicobacter pylori (HP): lizhuwei triple (bismuth potassium citrate tablet clarithromycin tablet tinidazole tablet), the treatment group took "Ya Jie Sha Ba" capsule on the basis of Lizhuwei triple therapy. Both groups took 10 days as a course of treatment, after 10 days of treatment, Observe and record the symptom score before and after treatment in two groups (2) the change of tongue coating in two groups (3) adverse reactions in the course of treatment in two groups) the safety index before and after treatment in the treatment group was 4 weeks after reexamination of HP infection. HP eradication rate was observed in both groups. The result is 1: 1. After 10 days of treatment, the symptom score of the treatment group was significantly lower than that of the control group (P < 0.05). After 10 days of treatment, the difference of tongue coating distribution between the two groups was statistically significant (P 0.05. 3). After treatment, there was no significant difference between the two groups in the symptoms of epigastric pain, stomachache, stomach noise, nausea and vomiting. The eradication rate of HP in the treatment group was 75.0. There was no significant difference between the HP eradication rate of the treatment group and that of the control group (65.8%). The safety indexes of the treatment group were not abnormal. The incidence of adverse reactions during treatment was compared between the two groups (P 0.05), and the difference was statistically significant. Conclusion: 1. The number of male patients with HP associated gastritis was significantly higher than that of female patients with Hp-associated gastritis. Compared with patients treated with triple therapy alone, the symptoms of epigastric distension and stool sclerotherapy were significantly improved in patients with combined use of yajieshaba, while the pain in the stomach, the elimination of good hunger, and the noise in the stomach. There was no significant difference between the two groups in other major symptoms, such as nausea and vomiting. After the eradication of HP therapy, the regression effect of the patients treated with Ya-Jie Sha Ba was better than that of the group treated with Lizhuwei alone. It is shown that "Ya Jie Sha Ba" can effectively clear away the internal heat evil and prevent the eradication of the symptoms of heat reduction in the course of HP treatment. 4. "the eradication rate of HP in combination with Lizhouwei triple therapy was 75.0. 5%. Ya Jie Sha Ba can effectively reduce the incidence of adverse reactions in triple therapy, and its clinical application is safe and effective.
【學(xué)位授予單位】：云南中醫(yī)學(xué)院
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R573.3

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