發(fā)布時間：2018-05-26 05:13

  本文選題：肝疾病 + 脂肪肝　； 參考：《重慶醫(yī)學》2017年15期

【摘要】：目的系統(tǒng)評價利拉魯肽治療非酒精性脂肪肝病(NAFLD)的療效。方法計算機檢索Pubmed、EMBASE、the Cochrane library、中國知網(wǎng)、萬方數(shù)據(jù)庫和中文科技期刊數(shù)據(jù)庫,收集利拉魯肽治療NAFLD的隨機臨床對照研究(RCT),按排除和納入標準篩選文獻后,將納入文獻進行質(zhì)量評價并提取相應的數(shù)據(jù)后采用RevMan5.3軟件進行Meta分析。結(jié)果共納入7個RCT共計500例非酒精性脂肪性肝病患者。使用利拉魯肽12~48周后,可顯著改善非酒精性脂肪性肝病患者的組織學特征,并降低患者血清中的丙氨酸氨基轉(zhuǎn)移酶水平[加權(quán)均數(shù)差(WMD)=-25.32,95%CI(-37.22,-13.41),P0.01]和天冬氨酸氨基轉(zhuǎn)移酶水平[WMD=-24.56,95%CI(-35.10,-14.03),P0.01]。但并不能降低患者的血清中三酰甘油水平[WMD=-14.38,95%CI(-48.95,-20.20),P=0.42]和總膽固醇水平[WMD=-15.55,95%CI(-36.20,-5.10),P=0.14]。結(jié)論利拉魯肽對NAFLD有一定的治療作用。
[Abstract]:Objective to evaluate the therapeutic effect of Lilaru peptide in the treatment of non-alcoholic fatty liver disease (NAF LDD). Methods A computerized search was conducted for Pubmedan EMBASEN the Cochrane library.China knowledge Network, Wanfang Database and Chinese Science and Technology Journal Database were used to collect the randomized clinical controlled study on the treatment of NAFLD with liraluP, and the literature was screened according to the exclusion and inclusion criteria. The quality of literature was evaluated and the corresponding data were extracted. Meta analysis was carried out with RevMan5.3 software. Results A total of 500 patients with non-alcoholic fatty liver disease were included in 7 RCT. After 48 weeks of treatment, the histopathological characteristics of patients with non-alcoholic fatty liver disease were significantly improved and the serum levels of alanine aminotransferase (alt) in patients with non-alcoholic fatty liver disease were significantly improved [WMD-25.32C95CI-37.22U -13.41 P0.01] and aspartate aminotransferase levels (WMD-24.56-95CI-35.10- 14.03P0.01). But it did not decrease the serum triacylglycerol level [WMD-14.38 / 95] and the total cholesterol level [WMD-15.595 / CI-36.20 / -5.10 / P0.14]. Conclusion Lilaru peptide has a certain therapeutic effect on NAFLD.
【作者單位】： 四川大學華西醫(yī)院臨床藥學部;四川大學臨床藥學與藥物不良反應研究室;四川大學華西醫(yī)院老年科;四川大學分子醫(yī)學中心/生物治療國家重點實驗室;
【分類號】：R575.5

【相似文獻】

相關(guān)期刊論文 前1條

1 金惠琳;趙紅燕;李媛紅;賈樹爾;馬琳娜;;利拉魯肽在2型糖尿病合并脂肪肝治療中的臨床觀察[J];哈爾濱醫(yī)藥;2014年04期

相關(guān)博士學位論文 前1條

1 白蓮;利拉魯肽對2型糖尿病非酒精性脂肪肝的作用及機制研究[D];天津醫(yī)科大學;2014年

相關(guān)碩士學位論文 前6條

1 石志平;利拉魯肽降低2型糖尿病非酒精性脂肪肝大鼠肝臟磷酸化JNK的蛋白表達[D];河北醫(yī)科大學;2015年

2 唐婷;利拉魯肽對體外誘導的非酒精性脂肪肝細胞內(nèi)質(zhì)網(wǎng)應激的作用[D];河北醫(yī)科大學;2016年

3 劉鑫;利拉魯肽對體外誘導的非酒精性脂肪肝細胞LC3Ⅱ、p62表達的影響[D];河北醫(yī)科大學;2016年

4 范炳格;利拉魯肽對高糖環(huán)境下大鼠肝星狀細胞增殖的影響及與ERK信號通路關(guān)系研究[D];河北醫(yī)科大學;2016年

5 高慧亭;利拉魯肽對非酒精性脂肪肝病的作用及JNK信號通路的影響[D];南方醫(yī)科大學;2014年

6 李s，

本文編號：1936071