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  本文關鍵詞： APRI FIB-4 肝衰竭 預后　出處：《新疆醫(yī)科大學》2017年碩士論文　論文類型：學位論文

【摘要】：目的:探究APRI評分及FIB-4指數(shù)在慢性肝衰竭預后評估中的應用價值。方法:回顧性分析2005年3月至2014年9月隨訪期滿3個月的新疆醫(yī)科大學第一附屬醫(yī)院感染性疾病中心426例慢性肝衰竭患者資料,計算患者診斷為慢性肝衰竭時的MELD評分、APRI評分及FIB-4指數(shù)。應用單因素及多因素分析,繪制受試者工作特征曲線(ROC曲線),評價各評分方法預測患者3個月預后的價值。結果:單因素分析顯示APRI評分在生存組和死亡組之間差異無統(tǒng)計學意義(P0.05),FIB-4指數(shù)在生存組和死亡組之間差異有統(tǒng)計學意義(P0.05),多因素分析示APRI評分及FIB-4指數(shù)在生存組和死亡組之間均有統(tǒng)計學意義(P0.05);MELD評分、APRI評分、FIB-4指數(shù)AUC分別為0.6353、0.4888、0.6162,MELD評分和FIB-4指數(shù)與APRI評分間差異有統(tǒng)計學意義(P0.05),其中MELD評分及FIB-4指數(shù)間差異無統(tǒng)計學意義(P0.05),當MELD評分大于28分、FIB4指數(shù)大于11.27分時患者3個月病死率高,預后差;426例患者中,FIB-43.25者(n=59),病死率為33.9%,大于3.25者共367例,病死率為61.04%,差異有統(tǒng)計學意義(P0.05)。結論:APRI評分在評估慢性肝衰竭預后未顯示應用價值,FIB-4指數(shù)在慢性肝衰竭預后評估中有應用價值,其預測慢性肝衰竭價值不差于MELD評分,且FIB-4指數(shù)越高,慢性肝衰竭預后越差。
[Abstract]:Objective: to explore the value of APRI score and FIB-4 index in evaluating the prognosis of chronic liver failure. Methods: the infectious diseases in the first affiliated Hospital of Xinjiang Medical University were analyzed retrospectively from March 2005 to September 2014. Data of 426 patients with chronic liver failure, The MELD score and FIB-4 index of the patients with chronic liver failure were calculated. Univariate and multivariate analysis were used. Results: univariate analysis showed that there was no significant difference in APRI score between survival group and death group. There was significant difference between survival group and death group (P 0.05). Multivariate analysis showed that APRI score and FIB-4 index were statistically significant between survival group and death group. AUC of AUC was 0.63530.48880.86162meld, FIB-4 index and APRI. There was no significant difference between MELD score and FIB-4 index (P 0.05). When the MELD score was more than 28 points and the FIB4 index was greater than 11.27, the mortality rate was higher in 3 months. In 426 patients with poor prognosis, there were 43.25 cases with FIB-43.25 and 367 cases with fatality rate of 33.9and more than 3.25, respectively. The mortality rate was 61.04, and the difference was statistically significant (P 0.05). Conclusion the value of FIB-4 index in evaluating the prognosis of chronic liver failure is not significant. The value of FIB-4 index in predicting the prognosis of chronic liver failure is not worse than that of MELD score. The higher the FIB-4 index, the worse the prognosis of chronic liver failure.
【學位授予單位】：新疆醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R575.3

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