本文關(guān)鍵詞：補(bǔ)片在婦產(chǎn)科疾病中的臨床應(yīng)用及其生物相容性，由筆耕文化傳播整理發(fā)布。

背景：生物補(bǔ)片是重要的盆底組織替代物,能夠替代薄弱受損的盆底筋膜組織,在盆底重建中的應(yīng)用越來(lái)越廣泛,但有關(guān)其療效及生物相容性研究卻少有報(bào)道。 目的：探討生物補(bǔ)片在婦產(chǎn)科疾病中的臨床應(yīng)用及其生物相容性。 結(jié)果與結(jié)論：盆底修復(fù)及重建的材料作為盆底組織替代物能替代薄弱受損的盆底筋膜組織,目前大致包括生物材料、人工合成材料兩類。各種修補(bǔ)材料均有優(yōu)缺點(diǎn)。

中國(guó)組織工程研究 第16卷 第12期 2012–03–18出版

Chinese Journal of Tissue Engineering Research March 18, 2012 Vol.16, No.12

補(bǔ)片在婦產(chǎn)科疾病中的臨床應(yīng)用及其生物相容性

宋 利

Clinical application and biocompatibility of patch in obstetrics and gynecology diseases

Song Li Abstract

BACKGROUND: Biological patch is an important substitute of pelvic floor tissue, which can replace the impaired pelvic fascia tissue and has been widely used in pelvic floor reconstruction, but its efficacy and biocompatibility remain poorly studied. OBJECTIVE: To study the clinical application and biocompatibility of biological patch in obstetrics and gynecology disease. METHODS: An online computer-based retrieval of PubMed database and VIP database between January 1990 and December 2011 was performed for articles related to clinical application and biocompatibility of biological patch in obstetrics and gynecology disease. English key words were “obstetrics, gynecology diseases, treatment”, and Chinese key words were “patch, gynecologic and obstetric diseases, treatment”. A total of 192 literatures were screened, and 22 documents were eventually involved in the analysis.

RESULTS AND CONCLUSION: Pelvic floor tissue substitutes for pelvic floor repair and reconstruction can replace the impaired pelvic fascia tissue, and can be divided into biological materials and synthetic materials. A variety of repairing materials have their advantages and disadvantages. In all types of implants, autologous tissue, allograft and xenograft are prone to infection, abrasion, poor biocompatibility after implantation, so they are not applicable as the reconstruction materials. The synthetic absorbable patch is strong, easy to use, but prone to infection, rejection and erosion, showing a poor biocompatibility. Synthetic

nonabsorbable patch and acellular patch have low infection rate, few complications, and good biocompatibility. A large-size prospective case-controlled study for a longer follow-up visits are required to determine which kinds of patch materials are optimal and how is long-term efficacy results.

Song L. Clinical application and biocompatibility of patch in obstetrics and gynecology diseases. Zhongguo Zuzhi Gongcheng Yanjiu. 2012;16(12): 2253-2256. [ ]

摘要

背景：生物補(bǔ)片是重要的盆底組織替代物，，能夠替代薄弱受損的盆底筋膜組織，在盆底重建中的應(yīng)用越來(lái)越廣泛，但有關(guān)其療效及生物相容性研究卻少有報(bào)道。

目的：探討生物補(bǔ)片在婦產(chǎn)科疾病中的臨床應(yīng)用及其生物相容性。

方法：應(yīng)用計(jì)算機(jī)檢索1990-01/2011-02 PubMed數(shù)據(jù)庫(kù)及維普數(shù)據(jù)庫(kù)有關(guān)生物補(bǔ)片在婦產(chǎn)科疾病中的臨床應(yīng)用及其生物相容性方面的相關(guān)文獻(xiàn)，英文檢索詞“obstetrics，gynecology diseases，treatment”，中文檢索詞為“補(bǔ)片，婦產(chǎn)科疾病，治療”。檢索文獻(xiàn)量總計(jì)192篇，最終納入符合標(biāo)準(zhǔn)的文獻(xiàn)22篇。

結(jié)果與結(jié)論：盆底修復(fù)及重建的材料作為盆底組織替代物能替代薄弱受損的盆底筋膜組織，目前大致包括生物材料、人工合成材料兩類。各種修補(bǔ)材料均有優(yōu)缺點(diǎn)。在各種類型植入物中，自體組織、同種異體移植物、異種移植物植入后易感染，磨損，生物相容性較差，作為重建材料并不合適。合成的可吸收補(bǔ)片材料堅(jiān)固，應(yīng)用方便，但可能發(fā)生感染、排斥和侵蝕等并發(fā)癥，生物相容性較差。合成的不可吸收補(bǔ)片和脫細(xì)胞補(bǔ)片感染發(fā)生率低，并發(fā)癥少，生物相容性較好。但應(yīng)用哪種補(bǔ)片材料更佳及遠(yuǎn)期療效等均有待于延長(zhǎng)隨訪時(shí)間、大規(guī)模前瞻性病例對(duì)照研究加以驗(yàn)證。 關(guān)鍵詞：重度盆腔臟器脫垂；全盆底重建；補(bǔ)片；生物材料；人工合成材料；綜述文獻(xiàn) doi:10.3969/j.issn.1673-8225.2012.12.038

宋利. 補(bǔ)片在婦產(chǎn)科疾病中的臨床應(yīng)用及其生物相容性[J].中國(guó)組織工程研究，2012，16(12):2253-2256. [ ]

以下特性：①最小的異物反應(yīng)。②有彈性可彎0 引言 曲。③容易縫合。④較好的組織相容性。⑤允許膠原纖維長(zhǎng)入。⑥能夠使組織永久的修復(fù)。盆腔臟器脫垂和壓力性尿失禁是嚴(yán)重影響⑦具有較好的張力。⑧能夠抗感染。⑨較少的中、老年婦女生活質(zhì)量的常見(jiàn)病。隨著生活水并發(fā)癥。

平日益提高，關(guān)于此類疾病的研究愈加受到重當(dāng)前，補(bǔ)片材料有以下幾種：①合成的不視，盆底重建外科成為一門新興的學(xué)科。常規(guī)可吸收補(bǔ)片。②合成的可吸收補(bǔ)片。③自體或治療盆腔臟器脫垂的手術(shù)方式是陰式子宮切除異體移植物。一般來(lái)講，用作重建材料的自體和陰道前、后壁修補(bǔ)，此種方式有較高的復(fù)發(fā)組織具有以下優(yōu)點(diǎn)：無(wú)黏膜磨損、不存在疾病率[1]。近年來(lái)，為降低手術(shù)復(fù)發(fā)率，進(jìn)行了各種傳播的危險(xiǎn)，且感染率極低，但可能存在與筋手術(shù)方式的探討，包括補(bǔ)片的應(yīng)用。根據(jù)盆底膜采集相關(guān)的并發(fā)癥，如下肢或腹部的采集性組織修復(fù)的特點(diǎn)，理想的盆底重建材料應(yīng)具有

創(chuàng)傷等。合成材料則具有性質(zhì)穩(wěn)定、堅(jiān)固、應(yīng)

ISSN 1673-8225 CN 21-1581/R CODEN: ZLKHAH Department of

Obstetrics and Gynecology,

Shenyang Medical College Affiliated Fengtian Hospital, Shenyang 110024, Liaoning Province, China

Song Li, Associate chief physician, Department of Obstetrics and Gynecology,

Shenyang Medical College Affiliated Fengtian Hospital, Shenyang 110024, Liaoning Province, China

Jiaysheny100@ 126.com

Received: 2012-01-15 Accepted: 2012-02-07

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