發(fā)布時(shí)間：2019-08-06 10:32

【摘要】：目的比較右美托咪定注射劑和丙泊酚注射劑在小兒磁共振(MRI)檢查中的鎮(zhèn)靜效果。方法將90例1~6歲進(jìn)行3.0TMRI檢查的患兒隨機(jī)分為試驗(yàn)組和對(duì)照組,每組45例。對(duì)照組靜脈泵注丙泊酚負(fù)荷劑量2.5 mg·kg~(-1),給藥時(shí)間10 min,接著給予80~100μg·kg~(-1)·min~(-1)維持;試驗(yàn)組靜脈泵注右美托咪定負(fù)荷劑量1μg·kg~(-1),給藥時(shí)間10 min,接著給予0.3~0.8μg·kg~(-1)·h~(-1)維持。記錄給藥前(T0)、給藥后10 min(T_1)、開始檢查前(T_2)、MRI檢查開始后5min(T_3)、MRI檢查完畢(T_4)、患兒返回病房(T_5)的平均動(dòng)脈壓(MAP)、心率(HR)、脈搏氧飽和度(Sp O2)、呼吸頻率(RR)、鎮(zhèn)靜起效時(shí)間、蘇醒時(shí)間、蘇醒后煩躁發(fā)生率、藥物不良反應(yīng)、MRI檢查質(zhì)量和時(shí)間。結(jié)果與T0比較,試驗(yàn)組患兒T_1-T_4的MAP和HR降低(P0.05),T5恢復(fù)至基礎(chǔ)水平;對(duì)照組在T_1-T_4MAP、RR降低(P0.05),T_5時(shí)點(diǎn)恢復(fù)至基礎(chǔ)水平,與試驗(yàn)組比較,在T1-T3MAP和RR顯著低于試驗(yàn)組(P0.05),在T_1-T_4HR顯著高于試驗(yàn)組(P0.05)。對(duì)照組鎮(zhèn)靜起效時(shí)間和蘇醒時(shí)間顯著短于試驗(yàn)組(P0.05),但蘇醒后煩躁的發(fā)生率和低氧飽和度的發(fā)生率顯著高于試驗(yàn)組(P0.05)。試驗(yàn)組MRI的檢查質(zhì)量顯著高于對(duì)照組,檢查時(shí)間顯著短于對(duì)照組(P0.05)。結(jié)論與丙泊酚注射劑相比,右美托咪定注射劑在小兒磁共振檢查中能提供滿意的鎮(zhèn)靜深度,對(duì)患兒呼吸和血流動(dòng)力學(xué)影響小,藥物不良反應(yīng)發(fā)生率低,但是鎮(zhèn)靜的起效時(shí)間和蘇醒時(shí)間長(zhǎng)于丙泊酚。
[Abstract]:Objective to compare the sedation effect of dexmetomide injection and propofol injection in children with magnetic resonance (MRI). Methods 90 children aged 1 years and 6 years old were randomly divided into experimental group (n = 45) and control group (n = 45). In the control group, propofol loading dose was 2.5 mg kg~ (- 1), administration time was 10 min, and 80 ~ 100 渭 g kg~ (- 1) min~ (- 1) was maintained, while in the experimental group, the loading dose of right metomipramine was 1 渭 g kg~ (- 1), and the administration time was 10 min, followed by 0.3 ~ 0.8 渭 g kg~ (- 1) h ~ (- 1). Before administration (T0), 10 min after administration (T 鈮，

本文編號(hào)：2523499