本文選題：甲狀腺素 + 缺血-再灌注�。� 參考：《延邊大學(xué)》2005年碩士論文

【摘要】：多器官功能障礙綜合征是目前臨床中嚴(yán)重創(chuàng)傷和感染常見(jiàn)的并發(fā)癥,其死亡率較高。目前研究認(rèn)識(shí)到腸道細(xì)菌移位是產(chǎn)生細(xì)胞因子、炎癥介子的一個(gè)重要因素,繼而導(dǎo)致多器官功能障礙綜合征與高代謝狀態(tài),而細(xì)菌移位是腸黏膜屏障功能受損的后果。腸黏膜受到破壞,腸道細(xì)菌移位,很快導(dǎo)致腸源性細(xì)菌感染,細(xì)菌內(nèi)毒素則會(huì)激活細(xì)胞因子的釋放,誘導(dǎo)瀑布效應(yīng)的產(chǎn)生,導(dǎo)致臟器損害,甚至危及患者的生命,故保護(hù)腸黏膜屏障功能具有重要的意義。甲狀腺素是機(jī)體重要的內(nèi)分泌激素之一,其不僅對(duì)于維持心、腦等臟器的功能具有重要意義,而且近年研究還發(fā)現(xiàn)其對(duì)于肺、肝等均具有較明顯的保護(hù)作用。本實(shí)驗(yàn)?zāi)康脑谟谔接懩c缺血—再灌注24h時(shí)甲狀腺素的代謝異常和腸黏膜屏障破壞之間的關(guān)系,闡明補(bǔ)充外源性甲狀腺素對(duì)腸黏膜屏障功能保護(hù)的作用機(jī)制,為臨床防治多器官功能障礙綜合癥提供必要的理論基礎(chǔ)。方法:將Wistar大鼠39只隨機(jī)分為4組,即假手術(shù)組(S,n=12)、腸缺血—再灌注組(G,n=8)、腸缺血—再灌注+生理鹽水組(N,n=9)、腸缺血—再灌注+甲狀腺素組(T,n=10)。利用腸系膜上動(dòng)脈央閉法制作大鼠腸缺血—再灌注模型,并補(bǔ)充外源性甲狀腺素。24h后測(cè)定外周血游離甲狀腺素、促甲狀腺素、磷酸肌酸激酶和門(mén)靜脈血內(nèi)毒素水平,同時(shí)做腸黏膜形態(tài)學(xué)檢查。結(jié)果:再灌注24h后,G組和N組的血清甲狀腺素水平明顯低于S組,兩者之間有
[Abstract]:Multiple organ dysfunction syndrome is a common complication of severe trauma and infection. At present, it has been recognized that intestinal bacterial translocation is an important factor in the production of cytokines and inflammatory mesons, which leads to multiple organ dysfunction syndrome and hypermetabolic state, and bacterial translocation is the consequence of impaired intestinal mucosal barrier function. Intestinal mucous membrane is destroyed, intestinal bacteria are translocated, intestinal bacterial infection is caused quickly, bacterial endotoxin activates the release of cytokines, induces waterfall effect, causes organ damage, and even endangers the life of patients. It is important to protect intestinal mucosal barrier function. Thyroxine is one of the most important endocrine hormones in the body. It not only plays an important role in maintaining the function of organs such as heart and brain, but also has obvious protective effects on lung and liver. The purpose of this study was to investigate the relationship between abnormal thyroid hormone metabolism and intestinal mucosal barrier damage at 24 h after intestinal ischemia-reperfusion, and to elucidate the mechanism of protective effect of exogenous thyroxine on intestinal mucosal barrier function. To provide the necessary theoretical basis for clinical prevention and treatment of multiple organ dysfunction syndrome. Methods: Thirty-nine Wistar rats were randomly divided into 4 groups: sham operation group (n = 12), intestinal ischemia / reperfusion group (n = 8), intestinal ischemia / reperfusion normal saline group (n = 9), intestinal ischemia / reperfusion thyroxine group (n = 10). The rat model of intestinal ischemia-reperfusion was established by the method of superior mesenteric artery closure. The levels of free thyroxine, thyrotropin, creatine phosphokinase and endotoxin in portal vein blood were determined 24 hours after supplementation of exogenous thyroxine. At the same time, the morphology of intestinal mucosa was examined. Results: the serum thyroxine levels in group G and group N were significantly lower than those in group S after 24 hours of reperfusion.
【學(xué)位授予單位】：延邊大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2005
【分類(lèi)號(hào)】：R363

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 馬利,黎鰲,肖光夏,Edwin A Deitch;腸源性感染的實(shí)驗(yàn)研究[J];第三軍醫(yī)大學(xué)學(xué)報(bào);1990年01期

2 楊連粵,劉合利;甲狀腺素在外科中的應(yīng)用[J];中國(guó)實(shí)用外科雜志;2001年06期

3 張雅萍,王忠堂;B.B.R對(duì)嚴(yán)重?zé)齻�大鼠腸道屏障功能的保護(hù)作用[J];中國(guó)微生態(tài)學(xué)雜志;2002年05期

4 楊連粵,楊治力,王偉,彭吉祥,黃耿文;胰蛋白酶抑制劑對(duì)膿毒癥大鼠腸黏膜屏障的保護(hù)作用[J];中華普通外科雜志;2003年11期

5 陳馨,解偉光,姜會(huì)慶,汪軍,張新華,史利寧,劉效林;谷氨酰胺顆粒對(duì)燙傷小鼠小腸黏膜結(jié)構(gòu)的效應(yīng)[J];中華燒傷雜志;2001年06期

6 麻莉,劉友生;抗內(nèi)毒素治療的研究現(xiàn)狀[J];中華燒傷雜志;2003年03期

7 趙振林,李家成,王敬弘,馬杰,郭光偉;甲狀腺激素T_3增補(bǔ)于心臟停搏液中對(duì)心肌的保護(hù)作用[J];中華實(shí)驗(yàn)外科雜志;1999年06期

8 劉躍武,蔣朱明,徐艷英;化療后腸屏障功能損害及谷氨酰胺和生長(zhǎng)激素對(duì)腸粘膜屏障的作用[J];中華實(shí)驗(yàn)外科雜志;2001年01期

9 夏中元,王龍,陳雪君,劉先義;參附注射液對(duì)休克復(fù)蘇時(shí)腸黏膜保護(hù)作用機(jī)制的實(shí)驗(yàn)研究[J];中國(guó)急救醫(yī)學(xué);2001年08期

10 陳斌,付晉鳳,陳宗華,許琰,汪虹,李翠萍;口服精氨酸對(duì)燙傷大鼠腸缺血—再灌注損害的保護(hù)作用[J];中國(guó)急救醫(yī)學(xué);2002年10期

，

本文編號(hào)：2021167