發(fā)布時間：2018-02-15 10:18

  本文關(guān)鍵詞： 兔 氯胺酮-氟哌啶 氯胺酮 氯胺酮-芬太尼 復(fù)合麻醉　出處：《南京農(nóng)業(yè)大學(xué)》2005年碩士論文　論文類型：學(xué)位論文

【摘要】：實驗動物科學(xué)是生命科學(xué)研究的基礎(chǔ)和重要的支撐條件。人類各種疾病發(fā)生發(fā)展十分復(fù)雜，要想深入探討疾病的發(fā)病及防治機制，被稱為“活的精密儀器”的實驗動物，有著不可替代的作用。近年來，新西蘭兔由于個體的種種特性及優(yōu)勢，而被我院廣泛地應(yīng)用于動物外科實驗。但是，兔的麻醉問題常常困擾著我們，一方面是可供選擇的麻醉藥物較少(如常用的硫噴妥鈉、戊巴比妥鈉現(xiàn)已在市場上難以購到；氨基甲酸乙酯由于其自身的毒性，，現(xiàn)已逐漸被淘汰)，特別是我院所用的麻醉藥品均是臨床外科中人用的麻醉藥，缺乏專門用于兔的麻醉藥品；另一方面有關(guān)麻醉藥對兔生理機能的影響現(xiàn)在還知之甚少。因此，本實驗的目的是研究—種理想的兔復(fù)合麻醉方法，并探討復(fù)合麻醉對兔麻醉效果及其生理機能的影響。 實驗Ⅰ 兔氯胺酮與氟哌啶復(fù)合麻醉的實驗研究 本實驗?zāi)康氖怯^察應(yīng)用不同細合的氯胺酮與氟哌啶對兔復(fù)合麻醉效果。方法：48只健康新西蘭兔隨機分為6組，即Ⅰ(50mg氯+2.5mg氟)、Ⅱ(50mg氯+5mg氟)、Ⅲ(75mg氯+2.5mg氟)、Ⅳ(75mg氯+5mg氟)、Ⅴ(100mg氯+2.5mg氟)和Ⅵ(100mg氯+5mg氟)組，分別肌肉注射，通過觀察麻醉出現(xiàn)時間(以動物自然倒下、睫毛反射及角膜反射減弱為有效指標(biāo))、麻醉維持時間(以麻醉過程平穩(wěn)、胸腹式呼吸、肌肉完全松弛及鉗夾趾間組織偶爾可引起趾蹼反射為有效指標(biāo))、麻醉蘇醒時間(以頭抬起、肢體躁動及有痛感為有效指標(biāo))進行麻醉效果的評價(優(yōu)：術(shù)中無肢動行為；良：術(shù)中曾有影響手術(shù)操作的肢動活動；差：術(shù)中肢體亂動，手術(shù)無法進行；死亡率：從手術(shù)開始至術(shù)后24h內(nèi)有無死亡為有效指標(biāo))。實驗結(jié)果顯示，Ⅰ、Ⅱ細麻醉效果差，麻醉維持時間短，分別為37±3min和42±3min。Ⅲ細麻醉效果良，麻醉維持時間為40±3min。Ⅳ、Ⅴ、Ⅵ細麻醉效果優(yōu)；但Ⅴ組麻醉維持時間較短(42±5min)，Ⅵ組雖麻醉維持時間長(75±5min)，但卻有死亡；Ⅳ組(75mg氯+5mg氟)·kg~(-1)術(shù)中肌肉松弛，無肢動行為，麻醉維持時間在45±5min，無死亡發(fā)生。結(jié)論：Ⅳ組(75mg氯胺酮·kg~(-1)+5mg氟哌定·kg~(-1)的麻醉效果最好，可滿足45min左右的手術(shù)實驗。
[Abstract]:Laboratory animal science is the foundation and important supporting condition of life science research. The occurrence and development of human diseases is very complicated. To study the pathogenesis and prevention mechanism of diseases, it is called "living precision instrument" experimental animals. In recent years, New Zealand rabbits have been widely used in animal surgery experiments because of their individual characteristics and advantages. On the one hand, there are fewer narcotic drugs available (such as the commonly used thiopental sodium, pentobarbital sodium, which is now difficult to buy on the market; ethyl carbamate) because of its own toxicity, The narcotic drugs used in our hospital have been gradually eliminated, especially those used in clinical surgery for human use and lack of narcotic drugs specifically used in rabbits. On the other hand, little is known about the effects of anesthetics on the physiological functions of rabbits. The purpose of this experiment was to study the ideal method of compound anesthesia in rabbits and to explore the effect of compound anesthesia on the anesthetic effect and physiological function of rabbits. Experimental study on compound Anesthesia of Ketamine and Haloperidol in Rabbits. The purpose of this experiment was to observe the effect of different fine combination ketamine and haloperidol on rabbit compound anesthesia. Methods Twenty eight healthy New Zealand rabbits were randomly divided into 6 groups. Groups 鈪

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