Ѫ֬ˮƽcHDLֲP(gun)ϵо
P(gun)I~ HDL (TG) đ̴(TC) ܶ֬đ̴(HDL-C) ܶ֬đ̴(LDL-C) pӾ-ӡEzy }Ӳ HDL (TG) ܶ֬đ̴(HDL-C) ܶ֬đ̴(LDL-C) p̎ĴW(xu)2006격ʿՓՓͣW(xu)λՓ
ժҪ һѪ{֬|(zh)cׁܶ֬P(gun)ϵ оĿģ }Ӳ(Atherosclerosis, As)Ԅ}Ѫܱ֬|(zh)eγӠwSʹѪܱӲĶؼ(x)đ̴ƽAsl(f)l(f)չD(zhun)P(gun)Ҫоܶ֬(HDL)ЌAsһҪęCƾHDLcđ̴D(zhun)\(RCT)܇(x)(}ڼ(x))(ni)^ʣđ̴ƳD(zhun)\KM(jn)D(zhun)^(jng)ǰŮԹIJl(f)ʵͬgg(sh)ػȻͣ(jng)ŮCHDl(f)CHDl(f)һѪ֬Ѫ֬HDLԄe HDLwСܶȡӾwMɼܘOһһ֬ɷ֞pre_1-HDLpre_2-HDLHDL_(3C)HDL_(3b)HDL_(3a)HDL_(2a)HDL_(2b)ȁСwPpre-HDLapoA͘O֬|(zh)Ҫ錧(do)(x)đ̴wHDL_2t^apoAđ̴c(x)đ̴D(zhun)\P(gun)Colvinڷ`LеһνʾHDLx^дwHDL]D(zhun)׃?yu)лСwHDL(Oܶ֬)СwHDLHD(zhun)^wHDL(wHDL)СwHDLԴСwHDL@ʾHDLǴx(wn)ijw^HDLHDLxͨ·ĽKa(chn)ֱӏѪ{Ƴ Сwǰ_1-HDLһϵøѪ{֬đ̴֬D(zhun)ø(LCAT)đ̴D(zhun)Ƶ(CETP)֬ø(HL)֬ø(LPL)֬D(zhun)Ƶ(PLTP)ʹHDLx^̾ǰ_1ǰ_2ǰ_3HDL_3HDL_2f׃^MiidaSaidiȡAsztalosđ̴ѪYpre_1-HDL@ӣ͵ĸ֬ѪYIJHDL_(2b)@҂^ȫęzy˸đ̴ѪY(HCL)߸֬ѪY(HTL)֬ѪY(MHL)IJ(CHD)ȻߵѪ{HDLֲl(f)F(xin)@Щ߶ڲ̶ͬȵѪ{HDLֲСwǰ_1-HDLǰ_2-HDLHDL_(3C)HDL_(3b)HDL_(3a)߶wHDL_(2a)HDL_(2b)p٣ʾHDLСwwijxRCTÜpy(tng)ӋYϱ@NHDLĮֲcİl(f)͇(yn)س̶ȶ@P(gun)P(gun)^ѪHDL-CѪ{HDLMɼ׃urAsCHDΣUԼ(yn)س̶ȵһָ(bio)֬ѪYAsCHDѪ{HDLֲF(xin)ԽԽP(gun)עȫzyAsP(gun)(֬ѪYxCϰYIJ)HDLNֲЈeϵy(tng)ظ(j)đ̴ӋATPļքeѪ{(TG)đ̴(TC)HDL-CԼLDL-CˮƽԔ(x)оѪиN֬|(zh)ɷHDLMHDLxԼRCTõӰ(ni)δҊ Ѫ{֬|(zh)cHDLP(gun)ϵо ͷ ЌҪĴW(xu)ĴW(xu)AW(xu)Ľٲ֞wz(442гɶ^(q)292185Ů105ꖵ^(q)150118Ů32)g33-78q20015đ̴Ӌ(NCEP)ίҽM(ATP)l(f)ĵļ(ATP-)(bio)(zhn)ԇѪ{TGˮƽ֞飺TG(TG1.69mmolL)MTG(TG1.69mmolL)MٰԇѪ{TCHDL-CLDL-CM(jn)зӡͬӰԇѪ{TCˮƽ֞飺TCmˮƽ(5.17mmolL)MTC(5.17mmolL)MٰԇѪ{TGM(jn)з TCMTG200TCmˮƽ(5.17 mmolL)M80TC߅Ը(5.17-6.21 mmolL)M75TC(6.21 mmolL)M45TG242TCmˮƽM90TC߅Ը߁M87TCM65 HDL-CM200TGУеHDL-C(1.03 mmolL)M19HDL-Cmˮƽ(1.03-1.55 mmolL)M116HDL-C(1.55mmolL)M65242TGHDL-CM23HDL-CmˮƽM86HDL-CM33 LDL-CM200TGLDL-Cmˮƽ(2.59 mmolL)M34LDL-Cӽm(2.59-3.34 mmolL)M50LDL-C߅Ը(3.36-4.11 mmolL)M67LDL-C(4.14-4.89 mmolL)M34OLDL-C(4.91 mmolL)M15242TGLDL-CmˮƽM79LDL-CӽmM63LDL-C߅Ը߁M50LDL-CM33OLDL-CM17 TGMTCmˮƽ170TG(1.69mmolL)M80TG߅Ը(1.69-2.25mmolL)M16TG(2.26-5.64mmolL)M64TGO(5.65mmolL)M10272TCTGM120TG߅Ը߽M97TG߽M38TGO߽M17 Ѫ{(TG)đ̴(TC)HDL-Cøԇ(﹤̸g(sh)˾)y(dng)TG4.52mmolLLDL-CFriedewaldʽӋ(dng)TG4.52mmolLLDL-Cøԇ(﹤̸g(sh)˾)yҽѪHDLӡEzyM(jn)МyyõHDLٷֺcƷapoAHDL(apoAӋ)ĺ Y(ji) 1ԇȰѪ{TGˮƽ֞TG(TG1.69mmolL)MTG(TG1.69mmolL)MٷքeԇѪ{TCHDL-CLDL-CM(jn)зY(ji)£ (1)cTG(yng)Ⱥ^oՓǰѪ{TCHDL-CLDL-CӣTGȺСwpre_1-HDLwHDL_(2b)HDL_(2a) (2)Ѫ{TCˮƽoՓTGTGȺcTCmˮƽM^TCMСwpre_1-HDLHDL_(3b)@HDL_(2b)HDL_(2a)һSTCˮƽ׃׃ (3)Ѫ{HDL-CˮƽSHDL-CˮƽĽͣTGȺСwpre_1-HDLˮƽ]@׃TGȺڅеHDL-CM@ߡҟoՓTG(HDL_(2a))TGȺдwHDL_(2a)HDL_(2b)нڅݣеHDL-CMHDL_(2b)@͡ (4)Ѫ{LDL-CˮƽTGȺcLDL-CmˮƽM^OLDL-CMpre_1-HDLHDL_(3b)@ߣOLDL-CMHDL_(2b)@OLDL-CMHDL_(3c)HDL_(3a)@ߡTGȺLDL-COߺLDL-Cmˮƽ^Сwpre_1-HDLHDL_(3c)HDL_(3b)@ 2ԇȰѪ{TCˮƽ֞TCmˮƽ(5.17mmolL)MTC(5.17mmolL)MٷքeѪ{TGˮƽY(ji)l(f)F(xin) TCmˮƽTCȺУѪ{Сwper-_1-HDLHDL_(3a)@wHDL_(2a)HDL_(2b)@ͣڸTGԼTGO߁M^(yng)TGM 3ֲԪؚwP(gun)Сwpre_1-HDL@ҪP(gun)cTG((bio)(zhn)ؚwϵ(sh)[SRC]0.318p0.001)TC(SRC 0.461p0.001)HDL-C(SRC -0.129p0.001){(dio)жϵ(sh)(adjusted r~2)0.323ͬӵĴwHDL_(2b)@ҪP(gun)cTG(SRC -0.27p0.001)TC(SRC -0.233p0.001)HDL-C(SRC 0.138p=0.001)apo-A(SRC 0.424p0.001){(dio)жϵ(sh)0.422 Y(ji)Փ 1oՓTCLDL-CHDL-Cˮƽ߀ǵTGȺ^TGȺСwpre_1-HDLwHDL_(2b)@ȻTGˮƽӰHDLMɵһҪء 2TGȺHDL_(2b)m^TGM@ͣsSTC׃l(f)׃TGˮƽ׃^TCˮƽ׃ҪӰHDLMɵ 3mȻTGˮƽHDL-Cˮƽ͵ԇߣwHDL_(2b)@HDL-CԇRCTѽ(jng)pHDL-C(yng)rԼm 4TGȺpre_1-HDLHDL_(2b)m^TGȺ^̶ȵͣHDLSLDL-CӅsδҊ@׃TGcLDL-CˮƽHDLӰ푿ܛ]Ѕf(xi)ͬЧ(yng) 5SѪ{TGTCLDL-CˮƽHDL-CˮƽͣСwHDLӼwHDLpڅHDLx^đ̴D(zhun)\Üp Ѫ֬ˮƽͬԺŮHDLֲ׃ ͷ ͬϣATP-ļքeԄeԼԇѪ{TGHDL-CLDL-CM(jn)з TGMTG1.7 mmolLM(128Ů67)TG(1.7-2.5mmolL)M(65Ů24)ԼTG2.5mmolLM(110Ů48) LDL-CMLDL-C2.6 mmolLM(71Ů42)LDL-C(2.6-3.3 mmolL)M(68Ů35)ԼLDL-C3.3 mmolLM(164Ů62) HDL-CMHDL-C1.6mmolLM(70Ů28)HDL-C(1.0-1.6 mmolL)M(132Ů70)ԼHDL-C1.0 mmolLM(101Ů41) Ѫ{֬|(zh)HDLyͬǰѪd֬(apo)AB100CCEñƵĆߔUɢԇМy Y(ji) 1ԺŮSѪ֬TGLDL-CHDL-CĽBMITGTCLDL-CapoB100apoCapoCapoETGHDL-CAHDL-CapoA-t 2cŮTGTCLDL-CapoB100apoCapoCapoETGHDL-CHDL-CapoA-ߡ 3SѪ{TGԺŮԣTG2.5MTG1.7MСwpre_1-HDLHDL_(3a)@TG 1.72.5TG2.5MTG1.7MwHDL_(2a)HDL_(2b)@p١ 4SѪ{LDL-CԺŮLDL-C3.3MLDL-C2.6MȣСwpre_1-HDLHDL_(3b)HDL_(3c)(ԽM)@ӣLDL-C2.63.3LDL-C3.3MLDL-C2.6MwHDL_(2b)@p١ 5SѪ{HDL-CԺŮСwpre_1-HDLHDL_(3C)HDL_(3b)@wHDL_(2a)HDL_(2b)@pHDL-C 1.01.6HDL-C1.0MHDL-C1.6M 6ŮTG1.7TG 1.72.5Mc(yng)ԽMСwpre_1-HDL@͡ŮLDL-C2.6LDL 2.63.3HDL-C 1.01.6HDL-C1.0Mc(yng)ԽMwHDL_(2b)@ӡ Y(ji)Փ 1SѪ{TGLDL-CˮƽHDL-CˮƽСwHDLӼwHDLpڅݣHDLx^đ̴D(zhun)\Üp 2ŮHDLw^Դ@DzͬԄe}ӲcIJΣUԲԭ ڶЇѪ{ֲׁܶ֬gԄe оĿģ вW(xu)оCѪ{HDL-Cˮƽc}Ӳl(f)ΣUԳؓ(f)P(gun)вW(xu)о߀HDL-Cˮƽ1CHDΣUԽͼs1-2P(gun)ϵHDL-Cܼ(x)Kđ̴D(zhun)\(RCT)^еѪ{HDL-CܶNӰаgԄeʳʽЈ^(jng)ǰŮHDL-C^@ֽCHDԄeSgpٵĬF(xin)ǽоѪ{HDLֲ׃CHDl(f)Եĸеָ(bio) оLCATLPL֬ø(HTGL)CETPPLTPHDLxҪãӰHDLĽMLCATҪHDLxđ̴ʹHDL(jng)pre-HDLHDL_3HDL_2f׃x^̶uLPL܉ˮOܶ֬(VLDL)(CM)еTGʹֽ⣬ጷųapoA֬PLTPD(zhun)\HDL3HDL3֬࣬LCATҲM(jn)HDL_3D(zhun)׃?yu)HDL_2CETPɌHDL_2еCED(zhun)CMVLDLLDLVLDLLDLеTGD(zhun)\HDL_2HTGL܉ˮHDL_2еTG(dng)HDL_2еTGˮapoA֬SÓHDL_2D(zhun)׃?yu)HDL_3ÓapoA֬½Y(ji)ϳpre-HDLK֬ø(֬øHL)ˮN֬еTG(PL)ʹN֬wĴСܶȰl(f)׃ͨ^ώNø͵ӵHDL֮gƽB(ti)S֙Cwđ̴D(zhun)\ mȻ֬|(zh)ˮƽcԄegP(gun)ϵĈܶ࣬^оP(gun)עׁ֬ԄegоЇѪ{HDLֲԄegϵIJ ͷ ЌҪĴW(xu)ĴW(xu)AW(xu)Ľٲ֞wz(512гɶ^(q)362177Ů185ꖵ^(q)150118Ů32)g33-78q(54.78.2)ԇ߰Ԅeg^(jng)rֽM Ѫ{֬|(zh)d֬HDLyͬǰ Y(ji) 1Sgc(yng)30-39qM?c)?0-5960-6970qMBMITGTCapoB100apoCapoE@HDL-C@ 2c(yng)ԽM^Ů30-39q40-49qMTGapoCapoE@ͶHDL-C@ 3Sgc(yng)30-39qMȣ?c)?0-5960-6970qMСwpre_1-HDLpre_2-HDLHDL_(3b)@ 4(yng)ԽM^Ů30-39q40-49qMСwpre_1-HDL@pwHDL_(2b)@ 5ŮԽ^(jng)ǰͽ^(jng)^Լ^(jng)ǰŮԺԱ^l(f)F(xin)Сwpre_1-HDLHDL_(3b)@wHDL_(2a)HDL_2@p١ 6pre_1-HDLHDL_(2b)l(sh)ֲDаl(f)F(xin)l(sh)քeƺHDLw^ŮС 7ֲԪؚwP(gun)ԣСwpre_1-HDL@ҪP(gun)cTG((bio)(zhn)ؚwϵ(sh)[SRC]0.359p0.001)TC(SRC 0.444p0.001)HDL-C(SRC-0.216p0.001){(dio)жϵ(sh)(adjusted r~2)0.457ͬӵĴwHDL_(2b)@ҪP(gun)capo-C(SRC-0.123p=0.066)TG(SRC-0.170p0.01)TC(SRC-0.196p0.001)HDL-C(SRC 0.158p0.01)apoA-(SRC 0.442p0.001){(dio)жϵ(sh)0.422ŮԣСwpre_1-HDL@ҪP(gun)cTG(SRC 0.542p0.001)TC(SRC 0.286p0.001)apoA-(SRC 0.338p0.001)ͬӵĴwHDL_(2b)@ҪP(gun)cTG(SRC -0.362p0.001)TC(SRC -0.272p0.001)apoA-(SRC 0.385p0.001) Y(ji)Փ 1ЇѪ{HDLֲgԄeąֵ 2SgLHDLwʬF(xin)׃СڅʾRCTSgLМpA 3ŮHDLw^ԵĴ@NԄeSgLʧ 4^(jng)ŮHDLwСڽ^(jng)ǰŮмӰHDLx Ӱ푸߸ѪYK֬״xP(gun)IømRNA_(d) оĿģ оl(f)F(xin)߸ѪYHDLw׃СHDLx^đ̴D(zhun)\ÜpHDLwСܶȡӾwMɼܘOһһ֬סLCATͨ^HDLxđ̴M(jn)HDLpre_1-HDLHDL_3HDL_2D(zhun)׃ͳ죬ͬrҲSđ̴Ѫ{еķ(wn)B(ti)ƽLPLˮѪ{CMVLDLw̎TGƳѪѭh(hun)иTG֬M(jn)֬w֮g֬|(zh)cd֬Qc֬d֬ܶ֬D(zhun)HLˮN֬еTG(PL)ʹN֬wĴСܶȰl(f)׃SRB1錧(do)ܶ֬đ̴xԔzȡ^̡ApoA-HDLҪY(ji)(gu)ɷapoA-ɼLCATLCATđ̴đ̴HDLPennacchioоl(f)F(xin)^ȱ_(d)apoAD(zhun)СѪ{TGˮƽҰ͌13ʾapoAѪ{TGȵҪQ҂x߸ģоKapoA-apoA-LPLHLLCATSR-B1mRNA_(d)׃ϣʾ̼ˮB(yng)ɵĸ߸ѪY֬|(zh)֬״xɁyc_(d)rP(gun)ϵ ģͺͷ 12ֻWistaroʳ7քe(ÿ6ֻ)oʳ̼ˮʳ3KѪѪ֬KRNAͨ^RT-PCRzyapoA-apoA-LPLHLLCATSR-B1mRNA_(d)ˮƽapoA-ױ_(d)ˮƽʹWestern blotzy Y(ji) 1̼ˮB(yng)ѪTG@ѪHDL-C@ 2߸M͌սMȣapoA-mRNA͵ױ_(d)ˮƽ@ 3߸M͌սMȣapoA-LPLHLLCATԼSR-B1mRNA_(d)ˮƽδҊ@Բ Y(ji)Փ 1̼ˮB(yng)KapoA-mRNA͵ױ_(d)ˮƽ@@Sģ̈́ѪHDL-C@pٵԭ
[Abstract]:......
W(xu)λλĴW(xu)
W(xu)λeʿ
W(xu)λݡ2006
̖R341;R363
īI(xin)
P(gun)ڿՓ ǰ10l
1 Sϼ,SȺ,,{(ln),;ʹwܰͼ(x)Ѫһ[J];Ϻt(y)W(xu);200410
2 Z,,;ļSҺȡײĸM(jn)[J];Rđs־;198803
3 һ,¶,ϣ,AҰ,,W(xu)ӹ;θǰ׃ʽMɅ^(q)y״w(sh)׃x[J];܊t(y)W(xu)s־;199103
4 Oʾ,310006 ,ܬ310006;3wܰͼ(x)ѪΑB(ti)W(xu)߱ͷ[J];㽭t(y)W(xu);200206
5 ţ;Ȼwܰͼ(x)Ѫ\[J];A(ni)s־;200504
6 ꐺI;;B;ţ÷;;;;wίðRԇ[J];ЇˎcR;200912
7 ;ᘴ^ͻ|ā@Y(ji)(gu)о ͻ|(ni)ΰ|(zh)ĴwСᘴ^еW(xu)x[J];t(y)W(xu)ԺW(xu);1977Z1
8 Burghart Jilge;wDz;;(bio)ӛwеƄ[J];ƌW(xu)c;198502
9 ;һNޏ(f)մɵȺͽY(ji)(gu)[J];t(y)W(xu).ǻt(y)W(xu)փ;199605
10 ,,;Xˮо[J];l(wi)о;199003
P(gun)hՓ ǰ10l
1 ꐬ|;¼t;x;;;;СwȷY(ji)Ӱ[A];ȫwyԇW(xu)g(sh)hՓļ[C];2005
2 A;;;i;;{YBCOwĈF۵TEMо[A];ʮȫ@W(xu)hՓļ[C];2002
3 Sϼ;SȺ;;{(ln);ܺ;nP;;ʹwܰͼ(x)Ѫһ[A];At(y)W(xu)ڰ˴ȫѪҺW(xu)W(xu)g(sh)hՓąR[C];2004
4 ǺM(jn);Q;;;Ob;;;wTiO_2ĺϳɡ[A];2000'ȫW(xu)g(sh)hՓļ[C];2000
5 ľ;R;;AgwBaTiO_3ĤTEMо[A];2005ȫ@W(xu)hՓļ[C];2005
6 ǝMƽ;;HDLؘ(gu)w(ni)lipid-poorfree apoA a(chn)Ҫ;x[A];ČȫѪ֬cRW(xu)g(sh)ӑߵھŌȫ֬W(xu)g(sh)hՓąR[C];2008
7 ţ;;NKwܰͼ(x)Ѫ2沢īI(xin)(f)(x)[A];At(y)W(xu)ڰ˴ȫѪҺW(xu)W(xu)g(sh)hՓąR[C];2004
8 ܾS;;L;T;m;;;;CȡGdBa_2Cu_3O_(7-x)ĤabȡСwTEMо[A];ߴȫ@W(xu)hՓժҪ[C];1993
9 ߾w|;̘ɭ;;ߠto犲υ(sh)cֲӰ[A];2008ȫFa(chn)g(sh)hߟFļԣ[C];2008
10 s;;B(ti)ϵy(tng)̼ͨؕI(xin)[A];WTOЇƼcɳm(x)l(f)չ(zhn)cC؟(z)κ͌ߣσԣ[C];2002
P(gun)Ҫ ǰ10l
1 ؼsӛ ;(ni)ׂw⛷ĿͶԇ܇[N];Ї;2009
2 ;ַ̼a(chn)ߏȴwXˇоĿͨ^b[N];Їɫو;2003
3 ӛ xƼ;D(zhun)ć{w¹ˇɱ[N];Ї;2006
4 ;⛷ʣ(sh)Iҽr[N];r(nng)Y(do);2008
5 ;⛷ʣSֹ(yng)o[N];r(nng)Y(do);2008
6 ؼsӛ Ӿ;_ԪFr(nng)(w)M(jn)r(nng)[N];r(nng)Y(do);2006
7 ӛ Ф;ͬ(gu)⛷Ј[N];r(nng)Y(do);2005
8 ͨſƼɷ˾ e;OTN M(jn)횾CϿ][N];ͨŮa(chn)I(y);2007
9 ;⛷ʣBPCrٝq100Ԫ[N];r(nng)Y(do);2008
10 ӛ Ƽ ʷƼ;(ni)ׂw⛷ĿͶa(chn)[N];ľ;2009
P(gun)ʿW(xu)λՓ ǰ10l
1 ~;Ѫ֬ˮƽcHDLֲP(gun)ϵо[D];ĴW(xu);2006
2 ÷;⋻ϡԿƼ(yng)о[D];W(xu);2008
3 w;w{w܃(ni)Ҏ(gu)о[D];|̼g(sh)W(xu);2011
4 ;o늷ֲՓо[D];㽭W(xu);2008
5 Թ;џˮôwĄW(xu)о[D];ƼW(xu);2006
6 Θ;}_Nxo늻x僳eTiAlNĤӵо[D];|W(xu);2009
7 ;༉߶ɢʽB(ti)ּܷо[D];uƼW(xu);2008
8 RT;ǵȜֱؚ̃ͬӔ(sh)ֵģM[D];AпƼW(xu);2006
9 wx;ڵV|(zh)xΑB(ti)cD(zhun)׃^̵Ġt(ni)eо[D];㽭W(xu);2007
10 Ǝr;۱ϩ/۱ϩY(ji)(gu)γ׃W(xu)о[D];W(xu);2007
P(gun)TʿW(xu)λՓ ǰ10l
1 ;GCr15^ĩߴֲMČо[D];(ni)ɹſƼW(xu);2009
2 ;wB(ti)џˮϹˇğģԇߜ(wn)о[D];ƼW(xu);2001
3 ͢;wSB(ti)wW(xu)Եԇо[D];ƼW(xu);2003
4 ܊ƽ;wB(ti)ˮџˇģԇоɄW(xu)[D];ƼW(xu);2001
5 ÷;}_ƫ늻x僴wՓcо[D];BW(xu);2004
6 ½;wӄW(xu)о[D];ƼW(xu);2005
7 ~;Եо[D];AW(xu);2006
8 ëh;xɢwӷxcБ(yng)ӌо[D];W(xu);2007
9 ¹;׃}(ni)ĤǵijY(ji)(gu)[D];Їt(y)ƴW(xu);2007
10 Ƽ;woˮcY(ji)ˇ(sh)W(xu)ģо[D];AW(xu)Ժ;2001
ľ̖1503318
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