淫羊藿是一種常用的傳統(tǒng)中藥.黃酮類成分是淫羊藿的主要有效成分,其中淫羊藿苷是含量最高的單體成分,淫羊藿素是淫羊藿苷的代謝產(chǎn)物.最近10余年來,學者對淫羊藿提取物的藥理作用進行了許多研究,表明淫羊藿黃酮,尤其是淫羊藿苷及其衍生物,在骨質(zhì)疏松癥、骨關(guān)節(jié)炎、神經(jīng)和精神疾病、動脈粥樣硬化、哮喘和肺部疾病、炎癥性腸病、腎臟疾病、皮膚病、自身免疫性疾病和癌癥等多個與慢性炎癥有關(guān)的疾病模型中顯示了良好的抗炎作用.淫羊藿苷及其衍生物發(fā)揮抗炎作用的分子機制主要包括降低炎癥細胞因子釋放和NF-κB信號通路激活,抑制NLRP3/caspase-1/IL-1β、STAT和MAPK介導的信號傳導通路,上調(diào)Nrf2/ARE/HO-1信號通路以及糖皮質(zhì)激素受體和雌激素受體下游信號通路等.本文綜述了該領(lǐng)域的近期研究進展,提示淫羊藿及其所含的活性化合物具有治療多種慢性炎癥相關(guān)疾病的潛力.

【文章頁數(shù)】：15 頁

【文章目錄】：
1 Anti-inflammatory effects of Epimedium extracts in various diseases
    1.1 Bone diseases
        1.1.1 Osteoporosis and bone loss
        1.1.2 Osteoarthritis
        1.1.3 Septic arthritis and intervertebral disc degeneration
    1.2 Neurological and psychiaric disorders
        1.2.1 Alzheimer's disease
        1.2.2 Parkinson's disease
        1.2.3 Depression
        1.2.4 Ischemic stroke and spinal cord injury
    1.3 Cardiovascular diseases
        1.3.1 Heart diseases
        1.3.2 Atherosclerosis
        1.3.3 Diabetic vascular disorders
    1.4 Asthma and Lung diseases
    1.5 Kidney diseases
        1.5.1 Chronic kidney disease
        1.5.2 Acute renal damage
    1.6 Skin diseases
    1.7 Autoimmune disease
        1.7.1 Multiple sclerosis
        1.7.2 Inflammatory bowel diseases
        1.7.3 Rheumatoid arthritis and lupus nephritis
    1.8 Cancer
2 Molecular mechanisms of anti-inflammatory effects of Epimedium extracts
    2.1 Inflammatory cytokines
    2.2 TLR4/MyD88/NF-κB signaling pathway
    2.3 NLRP3/caspase-1/IL-1βaxis
    2.4 ERK/p38/JNK MAPK signaling pathway
    2.5 STAT and immune response
    2.6 Nrf2/ARE/HO-1 signaling pathway
    2.7 Glucocorticoid receptor and estrogen receptor signaling
3 Conclusion and prospect



本文編號：3995794