發(fā)布時(shí)間：2018-03-02 00:30

  本文關(guān)鍵詞： 炎癥性腸病 鈣衛(wèi)蛋白 Meta分析　出處：《重慶醫(yī)科大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:系統(tǒng)評(píng)價(jià)應(yīng)用糞便鈣衛(wèi)蛋白(fecal calprotectin,FC)診斷炎癥性腸病(inflammatory bowel disease,IBD)的臨床價(jià)值。方法:使用計(jì)算機(jī)在萬方數(shù)字化期刊全文數(shù)據(jù)庫、相關(guān)期刊論文(CNKI)、Pub Med、Embase數(shù)據(jù)庫進(jìn)行檢索。由兩名研究人員獨(dú)立查找應(yīng)用FC診斷IBD的文獻(xiàn),篩選出符合納入標(biāo)準(zhǔn)的文獻(xiàn)。使用QUADAS-2工具對(duì)所納入文獻(xiàn)進(jìn)行質(zhì)量評(píng)價(jià)。運(yùn)用Meta-Disc 1.40軟件對(duì)所提取數(shù)據(jù)進(jìn)行統(tǒng)計(jì)學(xué)分析,計(jì)算出匯總靈敏度、匯總特異度及其95%置信區(qū)間(95%confidence interval,95%CI)。并繪制出受試者工作特征曲線(summary receiver operating characteristic curve,SROC曲線),計(jì)算曲線下面積(area under curve,AUC)及Q*值。使用Stata14軟件判斷是否存在發(fā)表偏倚。結(jié)果:共有13篇文獻(xiàn)(共21組數(shù)據(jù)、1385例病例,其中IBD組721例,對(duì)照組664例)納入研究,Meta分析得出FC診斷IBD的匯總靈敏度為0.86(95%CI=0.84-0.88),匯總特異度為0.76(95%CI=0.74-0.79),SROC曲線下面積為0.9169,Q*值為0.8498。結(jié)論:FC對(duì)診斷IBD有較高的靈敏度、特異度,可用于臨床輔助診斷IBD。
[Abstract]:Objective: to systematically evaluate the clinical value of fecal calmodulin (fecal calprotectinus) in the diagnosis of inflammatory bowel disease (IBDs) of inflammatory bowel disease. The Chinese Journal Full-text Database (CNKI) was searched by the Pub Med-Embase database. Two researchers independently searched the literature on the diagnosis of IBD with FC. Select the documents that meet the inclusion criteria. Use the QUADAS-2 tool to evaluate the quality of the included documents. Use Meta-Disc 1.40 software to carry out statistical analysis of the extracted data, and calculate the aggregate sensitivity. Summarize the specificity and its 95% confidence interval. Summarize the receiver operating characteristic curve. Calculate the area under the curve and the QR *. Use the Stata14 software to determine whether there is a publication bias. Results:. 13 articles (21 groups of data, 1385 cases), Among them, 721 cases in IBD group and 664 cases in control group) Meta-analysis showed that the total sensitivity of FC in diagnosing IBD was 0.8695 CI0.84-0.88, and the aggregation specificity was 0.74-0.799.The area under the curve was 0.9169 Q* 0.84980.Conclusion IBD FC has higher sensitivity and specificity in the diagnosis of IBD. It can be used for clinical auxiliary diagnosis of IBD.
【學(xué)位授予單位】：重慶醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R574

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