本文關(guān)鍵詞：后循環(huán)缺血性卒中與認(rèn)知障礙相關(guān)性研究，由筆耕文化傳播整理發(fā)布。

后循環(huán)缺血性卒中與認(rèn)知障礙相關(guān)性研究

Correlation of Posterior Cerebral Artery Ischemic Stroke and Cognitive Impairment

[1] [2] [3] [4] [5] [6] [7] [8]

RUAN Jie;JI Ren-Jie;WEI Guo;ZHOU Qiong;SHEN He-Ping;MENG Fan-Xia;YUAN Huai-Wu;LUO Ben-Yan（ Department of Neurology, Hangzhou Geriatric Hospital, Hangzhou 310022, China）

[1]杭州市老年病醫(yī)院神經(jīng)內(nèi)科,杭州510022; [2]浙江大學(xué)醫(yī)學(xué)院附屬第一醫(yī)院神經(jīng)內(nèi)科;,杭州510022; [3]寧波市第一醫(yī)院神經(jīng)內(nèi)科;,杭州510022; [4]嘉興市第二醫(yī)院神經(jīng)內(nèi)科,杭州510022;

文章摘要：目的探究后循環(huán)缺血性卒中與認(rèn)知障礙發(fā)生的關(guān)系。方法連續(xù)選取2013年11月至2014年11月浙江大學(xué)醫(yī)學(xué)院附屬第一醫(yī)院及嘉興市第二醫(yī)院收治的急性后循環(huán)缺血性卒中患者67例,收集患者人口學(xué)、影像學(xué)及認(rèn)知功能評(píng)價(jià)資料,并通過磁共振成像統(tǒng)計(jì)梗死部位;通過簡明精神狀態(tài)量表、阿爾茲海默病評(píng)定量表認(rèn)知分量表、臨床癡呆量表評(píng)估認(rèn)知功能;根據(jù)認(rèn)知診斷標(biāo)準(zhǔn)同時(shí)結(jié)合認(rèn)知功能評(píng)價(jià)結(jié)果,將患者分為認(rèn)知功能正常組、血管性輕度認(rèn)知障礙組、血管性癡呆組。結(jié)果 67例患者中,認(rèn)知功能正常32例（47.8%）、血管性輕度認(rèn)知障礙20例（29.9%）,血管性癡呆15例（22.4%）。通過校正年齡、性別、漢密爾頓抑郁評(píng)分等因素后,多因素回歸分析顯示：顳枕葉缺血性卒中[比值比（odd ratio,OR）75.89,95%可信區(qū)間（confidence interval,CI）3.92~1 470.06）]增加認(rèn)知障礙發(fā)生風(fēng)險(xiǎn),腦橋缺血性卒中患者發(fā)生認(rèn)知障礙的風(fēng)險(xiǎn)比非腦橋缺血性卒中降低90%（OR 0.10,95%CI 0.02~0.60）;進(jìn)一步分析顯示,顳枕葉缺血性卒中（OR 542.24,95%CI 7.85~37 481.44）增加輕度認(rèn)知障礙發(fā)生風(fēng)險(xiǎn);小腦缺血性卒中（OR 12.49,95%CI 1.03~151.58）增加血管性癡呆發(fā)生風(fēng)險(xiǎn)。結(jié)論 50%以上后循環(huán)缺血性卒中患者發(fā)生認(rèn)知障礙;其中顳枕葉及小腦缺血性卒中增加認(rèn)知障礙發(fā)生風(fēng)險(xiǎn),腦橋缺血性卒中與認(rèn)知障礙發(fā)生無顯著相關(guān)性。

Abstr：Objective To investigate the relationship between posterior cerebral artery ischemic stroke and cognitive impairment.Methods Sixty-seven patients with acute posterior circulation ischemic stroke were continuously included from the first affiliated hospital of Zhejiang university and Jiaxing second hospital from November 2013 to November 2014. We collected demographic data, imaging data and evaluated cognitive function. Magnetic resonance imaging was used to calculate patients＇ infarction sections. Mini-Mental State Examination（MMSE）, Alzheimer＇s Disease Assessment Scale-cognitive subscales（ADAS-cog）, Clinical Dementia Rating scale（CDR） were used to evaluate cognition in post-stroke patients. According to cognitive impairment diagnosis standards, patients were divided into three groups： the normal cognitive function, the vascular mild cognitive impairment and the vascular dementia group.Results Among 67 enrolled patients, 32 patients had normal cognition（47.8%）, 20 patients had mild cognitive impairment（29.9%）, 15 patients had vascular dementia（22.4%）. Accoding to adjusting the age,sex,scores of Hamilton Depression Rating Scale,multivariate logistic regression analysis showed that, the odds ratio（OR） of cognitive impairment in patients with occipitotemporallobe ischemic stroke increased（OR =75.89, 95%CI 3.92-1470.06）,which in patients with pontine ischemic stroke reduced by 90%（OR =0.10, 95%CI 0.02-0.60）; the further analysis shows that, the odds ratio of mild cognitive impairment in patients with occipitotemporal lobe ischemic stroke increased further（OR =542.24, 95%CI 7.85-37481.44）; and the odds ratio of vascular dementia in patients with cerebellar ischemic stroke also increased（OR =12.49, 95%CI 1.03-151.58）.Conclusion More than Fifty percents patie

文章關(guān)鍵詞：

Keyword：:Posterior cerebral artery Ischemic stroke Cognitive impairment

課題項(xiàng)目：“十二五”國家科技支撐計(jì)劃（2011BAI08B02）; 浙江省醫(yī)藥衛(wèi)生一般研究項(xiàng)目（2015KYB122）

作者信息：會(huì)員可見

  本文關(guān)鍵詞：后循環(huán)缺血性卒中與認(rèn)知障礙相關(guān)性研究，由筆耕文化傳播整理發(fā)布。