高劑量與低劑量咖啡因治療早產(chǎn)兒原發(fā)性呼吸暫停效果及安全性研究
發(fā)布時(shí)間：2019-07-21 10:14
【摘要】：目的探討高劑量與低劑量咖啡因治療早產(chǎn)兒原發(fā)性呼吸暫停的臨床效果和安全性。方法選擇2014年8月—2016年8月洛陽(yáng)市婦女兒童醫(yī)療保健中心收治的早產(chǎn)兒原發(fā)性呼吸暫�；純�104例,采用隨機(jī)數(shù)字表法分為對(duì)照組和觀察組,每組52例。觀察組給予枸櫞酸咖啡因首次劑量為20 mg/kg,靜脈滴注時(shí)間在30 min以上,24 h后維持15 mg/kg,1次/d,在呼吸暫停消失7 d后停藥。對(duì)照組給予枸櫞酸咖啡因首次劑量為20 mg/kg,靜脈滴注時(shí)間在30 min以上,24 h后維持5 mg/kg,1次/d,在呼吸暫停消失7 d后停藥。觀察并記錄兩組患兒治療效果,治療第1天、第2天、第3天記錄呼吸暫停發(fā)生次數(shù)及呼吸暫停嚴(yán)重程度評(píng)分,用藥后可能發(fā)生的不良反應(yīng),兩組呼吸機(jī)使用次數(shù)及使用時(shí)間。結(jié)果觀察組治療效果優(yōu)于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(u=-2.717,P=0.007)。觀察組治療第1天、第2天、第3天呼吸暫停發(fā)生次數(shù)少于對(duì)照組,呼吸暫停嚴(yán)重程度評(píng)分低于對(duì)照組(P0.05)。兩組患兒心動(dòng)過(guò)速、煩躁不安、喂養(yǎng)困難、高血糖癥、低鉀血癥、總不良反應(yīng)發(fā)生率比較,差異均無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。觀察組患兒呼吸機(jī)使用率低于對(duì)照組,呼吸機(jī)使用時(shí)間短于對(duì)照組(χ~2=10.636,P0.05;t=2.232,P0.05)。結(jié)論高劑量咖啡因治療早產(chǎn)兒原發(fā)性呼吸暫停療效優(yōu)于低劑量,可減輕患兒臨床癥狀,減少呼吸暫停發(fā)生次數(shù),降低呼吸機(jī)使用率,值得臨床推廣。
[Abstract]:Objective to investigate the clinical effect and safety of high dose and low dose caffeine in the treatment of primary dyspnea in premature infants. Methods from August 2014 to August 2016, 104 premature infants with primary dyspnea were randomly divided into control group (n = 52) and observation group (n = 52). In the observation group, caffeine citrate was given intravenously for more than 30 min at the first dose of 20 mg/kg, maintained for 15 mg/kg,1 / d 24 hours later, and stopped after 7 days of apnea. The control group was given caffeine citrate for the first time at a dose of 20 mg/kg, for more than 30 min, maintained for 5 mg/kg,1 / d 24 hours later, and stopped taking caffeine for 7 days after Apnea disappeared. The therapeutic effect of the two groups was observed and recorded. On the first, second and third day of treatment, the frequency of Apnea and the score of severity of Apnea, the possible adverse reactions after treatment, the times and time of ventilator use in the two groups were recorded. Results the therapeutic effect of the observation group was better than that of the control group, and the difference was statistically significant (u 鈮，
本文編號(hào)：2517107
[Abstract]:Objective to investigate the clinical effect and safety of high dose and low dose caffeine in the treatment of primary dyspnea in premature infants. Methods from August 2014 to August 2016, 104 premature infants with primary dyspnea were randomly divided into control group (n = 52) and observation group (n = 52). In the observation group, caffeine citrate was given intravenously for more than 30 min at the first dose of 20 mg/kg, maintained for 15 mg/kg,1 / d 24 hours later, and stopped after 7 days of apnea. The control group was given caffeine citrate for the first time at a dose of 20 mg/kg, for more than 30 min, maintained for 5 mg/kg,1 / d 24 hours later, and stopped taking caffeine for 7 days after Apnea disappeared. The therapeutic effect of the two groups was observed and recorded. On the first, second and third day of treatment, the frequency of Apnea and the score of severity of Apnea, the possible adverse reactions after treatment, the times and time of ventilator use in the two groups were recorded. Results the therapeutic effect of the observation group was better than that of the control group, and the difference was statistically significant (u 鈮，
本文編號(hào)：2517107
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