国产伦乱,一曲二曲欧美日韩,AV在线不卡免费在线不卡免费,搞91AV视频

當(dāng)前位置:主頁 > 醫(yī)學(xué)論文 > 兒科論文 >

先天性馬蹄內(nèi)翻足與GDF5基因關(guān)聯(lián)研究

發(fā)布時(shí)間:2019-06-26 09:22
【摘要】:目的:檢測(cè)先天性馬蹄內(nèi)翻足患者和對(duì)照人群中GDF5基因的基因型分布情況,,探討GDF5基因單核苷酸多態(tài)性與先天性馬蹄內(nèi)翻足患者易感性之間的關(guān)聯(lián)性。 方法:病例組80名先天性馬蹄內(nèi)翻足患兒(漢族),年齡2周~3月;對(duì)照組86例,年齡3歲~6歲,收集靜脈血1.0ml并提取DNA,Taqman技術(shù)檢測(cè)GDF5基因單核苷酸多態(tài)性位點(diǎn)的不同等位基因、基因型在病例組和對(duì)照組的分布情況,統(tǒng)計(jì)分析與先天性馬蹄內(nèi)翻足患者易感性的關(guān)系。 結(jié)果:GDF5基因的單核苷酸多態(tài)性位點(diǎn)rs143383的病例組和對(duì)照組基因型構(gòu)成TT、TC、CC型其頻率病例組為56%、38%、6%;對(duì)照組為56%、37%、7%。等位基因T、C頻率病例組為75%、25%,病例組為74%、26%?ǚ綑z驗(yàn)兩者無顯著差異性,對(duì)性別的分層比較也沒有發(fā)現(xiàn)病例組與對(duì)照組的差異性。(P0.05) 結(jié)論:研究表明漢族人群中GDF5基因多態(tài)性位點(diǎn)可能與先天性馬蹄內(nèi)翻足的發(fā)病無關(guān)。
[Abstract]:Objective: to detect the genotypic distribution of GDF5 gene in patients with congenital equinovarus and control population, and to explore the association between single nucleotides polymorphism of GDF5 gene and susceptibility to congenital equinovarus. Methods: 80 children with congenital equinovarus (Han nationality) were enrolled in the case group, aged from 2 weeks to 3 months, and 86 patients in the control group, aged from 3 to 6 years old. Venous blood 1.0ml was collected and DNA,Taqman was extracted to detect the different alleles of GDF5 gene single nucleotides polymorphism, and the distribution of genotypes in the case group and the control group. The relationship between the polymorphism and the susceptibility of congenital equinovarus was statistically analyzed. Results: the frequency of TT,TC, CC was 56%, 38%, 6% in the case group, 56%, 37% and 7% in the control group, and 56%, 37%, 7% in the case group and the control group, respectively, and the frequency of TT,TC, CC was 56%, 38%, 6% in the case group and 7% in the control group. The frequency of C was 75%, 25% in the C frequency group, 74% and 26% in the case group. There was no significant difference in Chi-square test between the two groups, and there was no difference between the case group and the control group. (P 0.05) conclusion: the study shows that the polymorphism of GDF5 gene in Han population may not be related to the incidence of congenital equinovarus.
【學(xué)位授予單位】:蘇州大學(xué)
【學(xué)位級(jí)別】:碩士
【學(xué)位授予年份】:2012
【分類號(hào)】:R726.8

【參考文獻(xiàn)】

相關(guān)期刊論文 前4條

1 劉麗英;金春蓮;曹東華;趙寧;林長坤;孫開來;;COL9A1基因與先天性馬蹄內(nèi)翻足相關(guān)性的研究[J];遺傳;2007年04期

2 趙寧;金春蓮;劉麗英;曹東華;林長坤;吉士俊;孫開來;;COL1A1基因轉(zhuǎn)錄調(diào)控序列變異與單純性馬蹄內(nèi)翻足的相關(guān)性[J];遺傳;2008年06期

3 戴進(jìn);諸蓬生;朱倫慶;秦江輝;王珂杰;諸洪濤;趙寶成;史冬泉;蔣青;;生長分化因子5的基因多態(tài)性與先天性髖關(guān)節(jié)發(fā)育不良的相關(guān)性研究[J];中國骨與關(guān)節(jié)外科;2009年03期

4 任舒月,麻宏偉,姜俊,吉士俊,馬瑞雪,王大佳,陳秋;先天性馬蹄內(nèi)翻足與PAX5、PAX6和TBX3基因傳遞不平衡研究[J];中華小兒外科雜志;2004年05期



本文編號(hào):2506089

資料下載
論文發(fā)表

本文鏈接:http://lk138.cn/yixuelunwen/eklw/2506089.html


Copyright(c)文論論文網(wǎng)All Rights Reserved | 網(wǎng)站地圖 |

版權(quán)申明:資料由用戶ccee2***提供,本站僅收錄摘要或目錄,作者需要?jiǎng)h除請(qǐng)E-mail郵箱bigeng88@qq.com
国产欧美久久视频网站| 国产无码一区99| 青青草国产成人AV| 欧美日韩熟女一区三区| jingpinyiersan| 香蕉成人电影在线观看| 亚洲国产精品黄色A∨剧情| 日韩久久后入| 日本欧美韩国中文字幕| 美女国产操| 极品日韩内射777| 人人操欧美风骚| 制服丝袜人妻麻豆一本| 欧美成 人在线中文字幕| 欧美日韩成人在线观看网址| 欧美综合精品一区二区三区| 91小黄片免费看| 亚洲国产欧美中文不卡在线| 亚洲成人区电影| 天天干欧美天天干| 精品乱子一区二区三区在线观看| 国产精品一区香蕉视频| 亚洲a电影一区。| 久久精品国产精品亚洲>精品| 91视频中日韩欧美网| 小穴1080P在线| 在线少妇人妻你懂得| 超碰avwzw| 无码囯产综合AV在线| 久久久久久久国产精品影视无毛无套| 欧美精品005| 成人ai视频一区二区| 九色91视频地址国产大鸡巴| 日韩AV一卡二卡三卡无卡| 日本免费高清视频线观看| 精品麻豆久久123| 冰冰一区二区| 狠狠色婷婷久久综合图片| 久久欧美精品在线| 五月婷婷在线观看大香蕉| 亚洲日韩88|