發(fā)布時間：2018-01-09 15:01

  本文關鍵詞：體素內(nèi)不相干運動擴散加權成像在良性腦膜瘤中的初步臨床研究　出處：《廣州中醫(yī)藥大學》2017年碩士論文　論文類型：學位論文

  更多相關文章： 體素內(nèi)不相干運動擴散加權成像 磁共振成像 灌注 不同病理類型 良性腦膜瘤

【摘要】：目的:通過體素內(nèi)不相干運動擴散加權成像(Intravoxel Incoherent Motion Diffusion Weighted Imaging,IVIM-DWI)技術各相關參數(shù)(純擴散系數(shù),slow ADC或D;灌注分數(shù),f;偽擴散系數(shù),fast ADC或D*)在良性腦膜瘤(benign meningioma)中的應用價值,為臨床上手術方案的選擇及IVIM-DWI腦灌注技術的推廣應用提供一定的理論依據(jù)。方法:收集2016年2月至2017年1月來我院(廣州軍區(qū)廣州總醫(yī)院)就診并經(jīng)手術切除及病理結果最終證實為良性腦膜瘤的20例首診(未經(jīng)任何治療的)患者,均于術前行常規(guī)MRI序列、IVIM-MRI序列及增強MRI序列掃描,體素內(nèi)不相干運動擴散加權成像序列選用16個不同加權b值(范圍0～900s/mmm2),并通過采用IVIM-DWI技術經(jīng)典的雙指數(shù)模型分別記錄此20例良性腦膜瘤腫瘤實質(zhì)區(qū)與對側正常腦白質(zhì)區(qū)IVIM-DWI各相關參數(shù)(純擴散系數(shù),slow ADC或D;灌注分數(shù),f;偽擴散系數(shù),fast ADC或D*);另外,在單指數(shù)模型下單獨計算腫瘤實質(zhì)區(qū)與對側正常腦白質(zhì)區(qū)的表觀擴散系數(shù)(apparent diffusion coefficient,ADC),采用配對樣本t檢驗分別比較腦膜瘤腫瘤實質(zhì)區(qū)與正常腦白質(zhì)區(qū)的ADC、D、D*、f值,運用SPSS20.0統(tǒng)計學軟件對所測得的各個參數(shù)數(shù)據(jù)進行統(tǒng)計學分析(P0.05有統(tǒng)計學意義)。結果:1、單指數(shù)模型中,20例良性腦膜瘤患者腫瘤實質(zhì)區(qū)ADC值低于對側正常腦白質(zhì)區(qū)ADC值,兩者比較差異無統(tǒng)計學意義(t=-0.5037,戶0.05)。2、雙指數(shù)模型中,20例良性腦膜瘤患者腫瘤實質(zhì)區(qū)slow ADC值高于對側正常腦白質(zhì)區(qū)slow ADC值,兩者比較差異有統(tǒng)計學意義(t=3.0027,戶0.05)。3、雙指數(shù)模型中,20例良性腦膜瘤患者腫瘤實質(zhì)區(qū)fast ADC值高于對側正常腦白質(zhì)區(qū)fast ADC值,兩者比較差異無統(tǒng)計學意義(t=1.2863,P 0.05)。4、雙指數(shù)模型中,20例良性腦膜瘤患者腫瘤實質(zhì)區(qū)f值高于正常對側腦白質(zhì)區(qū)f值,兩者比較差異無統(tǒng)計學意義(t=-0.2221,戶0.05)。結論:IVIM-MRI作為一種新型的腦腫瘤灌注技術,相對于傳統(tǒng)的DWI-MRI來說是一種十分可靠的技術。IVIM雙指數(shù)模型D值可以準確描述良性腦膜瘤的水分子擴散信息,有助于擴大灌注技術的臨床應用范圍。
[Abstract]:Objective: through intravoxel incoherent motion diffusion weighted imaging (Intravoxel Incoherent Motion Diffusion Weighted Imaging, IVIM-DWI) of the related parameters (pure technology diffusion coefficient, slow ADC or D; f; perfusion fraction, pseudo diffusion coefficient, fast, ADC or D*) in benign meningioma (benign meningioma) application value, providing a theoretical basis for selection of clinical application on surgical operation and IVIM-DWI perfusion technique. Methods: from February 2016 to January 2017 in our hospital (Genenral Hospital of PLA Guangzhou Military Area) and treatment by surgical resection and pathological findings proved benign meningiomas in 20 cases of first diagnosed (untreated) patients, all the patients underwent routine MRI sequence, IVIM-MRI sequence and enhanced MRI sequence scanning, intravoxel incoherent motion diffusion weighted imaging sequences using 16 different weighted b value (0 ~ 900s/mmm2), and by using IVI The relevant parameters of the 20 cases of benign meningiomas in the tumor and contralateral normal brain white matter IVIM-DWI recorded double exponential model of classic M-DWI technique respectively (pure diffusion coefficient, slow ADC or D; f; perfusion fraction, pseudo diffusion coefficient, fast, ADC or D*); in addition, apparent diffusion coefficient calculation of the tumor parenchyma and contralateral normal brain white matter alone in the single index model under the table (apparent diffusion coefficient, ADC), paired sample t test were compared in parenchyma of meningiomas and normal brain white matter areas ADC, D, D*, F, using SPSS20.0 statistical software for statistical analysis of the measured data of each parameter are (statistically significant P0.05). Results: 1, the single index model, 20 patients with benign meningiomas in the parenchyma of the ADC value is lower than the contralateral normal brain white matter ADC values, there was significant difference between the two groups (t= -0.5037, 0.05.2), the double exponential model, 2 0 cases of patients with benign meningiomas tumor parenchyma slow ADC value is higher than the contralateral normal brain white matter slow ADC value, the difference was statistically significant (t=3.0027, 0.05).3, double exponential model, 20 patients with benign meningiomas in the parenchyma of fast ADC was higher than the contralateral normal brain white matter ADC values fast, no statistical significant difference (t=1.2863 P 0.05).4, double exponential model, parenchyma tumor patients in 20 cases of benign meningiomas f was higher than the normal contralateral cerebral white matter F values, there was significant difference between the two groups (t=-0.2221, 0.05). Conclusion: IVIM-MRI is a brain tumor model the perfusion technique, compared with the traditional DWI-MRI is a very reliable technology.IVIM double exponential model of D value of water molecules can accurately describe the benign meningioma diffusion information, clinical application and contribute to the expansion of perfusion technique.

【學位授予單位】：廣州中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R445.2;R739.45
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本文編號：1401830