發(fā)布時(shí)間：2018-01-09 15:01

  本文關(guān)鍵詞：體素內(nèi)不相干運(yùn)動(dòng)擴(kuò)散加權(quán)成像在良性腦膜瘤中的初步臨床研究　出處：《廣州中醫(yī)藥大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 體素內(nèi)不相干運(yùn)動(dòng)擴(kuò)散加權(quán)成像 磁共振成像 灌注 不同病理類型 良性腦膜瘤

【摘要】：目的:通過體素內(nèi)不相干運(yùn)動(dòng)擴(kuò)散加權(quán)成像(Intravoxel Incoherent Motion Diffusion Weighted Imaging,IVIM-DWI)技術(shù)各相關(guān)參數(shù)(純擴(kuò)散系數(shù),slow ADC或D;灌注分?jǐn)?shù),f;偽擴(kuò)散系數(shù),fast ADC或D*)在良性腦膜瘤(benign meningioma)中的應(yīng)用價(jià)值,為臨床上手術(shù)方案的選擇及IVIM-DWI腦灌注技術(shù)的推廣應(yīng)用提供一定的理論依據(jù)。方法:收集2016年2月至2017年1月來我院(廣州軍區(qū)廣州總醫(yī)院)就診并經(jīng)手術(shù)切除及病理結(jié)果最終證實(shí)為良性腦膜瘤的20例首診(未經(jīng)任何治療的)患者,均于術(shù)前行常規(guī)MRI序列、IVIM-MRI序列及增強(qiáng)MRI序列掃描,體素內(nèi)不相干運(yùn)動(dòng)擴(kuò)散加權(quán)成像序列選用16個(gè)不同加權(quán)b值(范圍0～900s/mmm2),并通過采用IVIM-DWI技術(shù)經(jīng)典的雙指數(shù)模型分別記錄此20例良性腦膜瘤腫瘤實(shí)質(zhì)區(qū)與對側(cè)正常腦白質(zhì)區(qū)IVIM-DWI各相關(guān)參數(shù)(純擴(kuò)散系數(shù),slow ADC或D;灌注分?jǐn)?shù),f;偽擴(kuò)散系數(shù),fast ADC或D*);另外,在單指數(shù)模型下單獨(dú)計(jì)算腫瘤實(shí)質(zhì)區(qū)與對側(cè)正常腦白質(zhì)區(qū)的表觀擴(kuò)散系數(shù)(apparent diffusion coefficient,ADC),采用配對樣本t檢驗(yàn)分別比較腦膜瘤腫瘤實(shí)質(zhì)區(qū)與正常腦白質(zhì)區(qū)的ADC、D、D*、f值,運(yùn)用SPSS20.0統(tǒng)計(jì)學(xué)軟件對所測得的各個(gè)參數(shù)數(shù)據(jù)進(jìn)行統(tǒng)計(jì)學(xué)分析(P0.05有統(tǒng)計(jì)學(xué)意義)。結(jié)果:1、單指數(shù)模型中,20例良性腦膜瘤患者腫瘤實(shí)質(zhì)區(qū)ADC值低于對側(cè)正常腦白質(zhì)區(qū)ADC值,兩者比較差異無統(tǒng)計(jì)學(xué)意義(t=-0.5037,戶0.05)。2、雙指數(shù)模型中,20例良性腦膜瘤患者腫瘤實(shí)質(zhì)區(qū)slow ADC值高于對側(cè)正常腦白質(zhì)區(qū)slow ADC值,兩者比較差異有統(tǒng)計(jì)學(xué)意義(t=3.0027,戶0.05)。3、雙指數(shù)模型中,20例良性腦膜瘤患者腫瘤實(shí)質(zhì)區(qū)fast ADC值高于對側(cè)正常腦白質(zhì)區(qū)fast ADC值,兩者比較差異無統(tǒng)計(jì)學(xué)意義(t=1.2863,P 0.05)。4、雙指數(shù)模型中,20例良性腦膜瘤患者腫瘤實(shí)質(zhì)區(qū)f值高于正常對側(cè)腦白質(zhì)區(qū)f值,兩者比較差異無統(tǒng)計(jì)學(xué)意義(t=-0.2221,戶0.05)。結(jié)論:IVIM-MRI作為一種新型的腦腫瘤灌注技術(shù),相對于傳統(tǒng)的DWI-MRI來說是一種十分可靠的技術(shù)。IVIM雙指數(shù)模型D值可以準(zhǔn)確描述良性腦膜瘤的水分子擴(kuò)散信息,有助于擴(kuò)大灌注技術(shù)的臨床應(yīng)用范圍。
[Abstract]:Objective: through intravoxel incoherent motion diffusion weighted imaging (Intravoxel Incoherent Motion Diffusion Weighted Imaging, IVIM-DWI) of the related parameters (pure technology diffusion coefficient, slow ADC or D; f; perfusion fraction, pseudo diffusion coefficient, fast, ADC or D*) in benign meningioma (benign meningioma) application value, providing a theoretical basis for selection of clinical application on surgical operation and IVIM-DWI perfusion technique. Methods: from February 2016 to January 2017 in our hospital (Genenral Hospital of PLA Guangzhou Military Area) and treatment by surgical resection and pathological findings proved benign meningiomas in 20 cases of first diagnosed (untreated) patients, all the patients underwent routine MRI sequence, IVIM-MRI sequence and enhanced MRI sequence scanning, intravoxel incoherent motion diffusion weighted imaging sequences using 16 different weighted b value (0 ~ 900s/mmm2), and by using IVI The relevant parameters of the 20 cases of benign meningiomas in the tumor and contralateral normal brain white matter IVIM-DWI recorded double exponential model of classic M-DWI technique respectively (pure diffusion coefficient, slow ADC or D; f; perfusion fraction, pseudo diffusion coefficient, fast, ADC or D*); in addition, apparent diffusion coefficient calculation of the tumor parenchyma and contralateral normal brain white matter alone in the single index model under the table (apparent diffusion coefficient, ADC), paired sample t test were compared in parenchyma of meningiomas and normal brain white matter areas ADC, D, D*, F, using SPSS20.0 statistical software for statistical analysis of the measured data of each parameter are (statistically significant P0.05). Results: 1, the single index model, 20 patients with benign meningiomas in the parenchyma of the ADC value is lower than the contralateral normal brain white matter ADC values, there was significant difference between the two groups (t= -0.5037, 0.05.2), the double exponential model, 2 0 cases of patients with benign meningiomas tumor parenchyma slow ADC value is higher than the contralateral normal brain white matter slow ADC value, the difference was statistically significant (t=3.0027, 0.05).3, double exponential model, 20 patients with benign meningiomas in the parenchyma of fast ADC was higher than the contralateral normal brain white matter ADC values fast, no statistical significant difference (t=1.2863 P 0.05).4, double exponential model, parenchyma tumor patients in 20 cases of benign meningiomas f was higher than the normal contralateral cerebral white matter F values, there was significant difference between the two groups (t=-0.2221, 0.05). Conclusion: IVIM-MRI is a brain tumor model the perfusion technique, compared with the traditional DWI-MRI is a very reliable technology.IVIM double exponential model of D value of water molecules can accurately describe the benign meningioma diffusion information, clinical application and contribute to the expansion of perfusion technique.

【學(xué)位授予單位】：廣州中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R445.2;R739.45
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本文編號：1401830