發(fā)布時(shí)間：2018-05-11 06:46

  本文選題：鋅缺乏 + 體脂�。� 參考：《衛(wèi)生研究》2017年03期

【摘要】：目的觀察邊緣性鋅缺乏對大鼠肥胖的影響。方法 SPF級成年雄性SD大鼠32只,隨機(jī)分為4組,低鋅組喂飼含6 mg/kg鋅的邊緣性鋅缺乏飼料,中鋅組喂飼含10 mg/kg鋅的邊緣性鋅缺乏飼料,低鋅對飼組和對照組喂飼正常鋅含量的AIN-93M飼料。喂養(yǎng)6周后,處死動物。測血鋅、血脂、血清瘦素含量,肝臟總抗氧化能力(T-AOC)、超氧化物歧化酶(SOD)、丙二醛(MDA)水平。結(jié)果低鋅組大鼠第5周起血鋅含量明顯低于低鋅對飼組和對照組(P0.05),成功建立邊緣性缺鋅模型。第6周時(shí),低鋅組大鼠脂體比明顯高于低鋅對飼組和對照組(P0.05);低鋅組和中鋅組大鼠肝臟MDA含量明顯高于對照組(P0.05);低鋅組和中鋅組大鼠肝臟TAOC、SOD水平明顯低于對照組(P0.05)。結(jié)論邊緣性鋅缺乏可增加肥胖發(fā)生的風(fēng)險(xiǎn),缺鋅組大鼠體內(nèi)氧化應(yīng)激升高可能是邊緣性鋅缺乏增加肥胖風(fēng)險(xiǎn)的主要原因。
[Abstract]:Objective to observe the effect of marginal zinc deficiency on obesity in rats. Methods Thirty-two adult male SD rats of SPF grade were randomly divided into 4 groups. The low zinc group was fed with marginal zinc deficiency diet containing 6 mg/kg zinc, while the middle zinc group was fed with 10 mg/kg zinc borderline zinc deficiency diet. Low zinc group and control group were fed with AIN-93M diet with normal zinc content. After 6 weeks of feeding, the animals were killed. The levels of serum zinc, serum lipid, serum leptin, total antioxidant capacity of liver, superoxide dismutase (SOD) and malondialdehyde (MDA) were measured. Results the serum zinc content in the low zinc group was significantly lower than that in the low zinc feeding group and the control group from the 5th week, and the marginal zinc deficiency model was successfully established. At the 6th week, the lipid body ratio of the rats in the low zinc group was significantly higher than that in the low zinc feeding group and the control group (P 0.05), the MDA content in the liver of the low zinc group and the middle zinc group was significantly higher than that of the control group (P 0.05), and the level of TAOCU SOD in the liver of the low zinc group and the middle zinc group was significantly lower than that of the control group (P 0.05). Conclusion Peripheral zinc deficiency can increase the risk of obesity. The increase of oxidative stress in rats with zinc deficiency may be the main reason for increasing the risk of obesity.
【作者單位】： 中國疾病預(yù)防控制中心營養(yǎng)與健康所國家衛(wèi)生計(jì)生委微量元素營養(yǎng)重點(diǎn)實(shí)驗(yàn)室;
【基金】：國家自然科學(xué)基金(No.81273073)
【分類號】：R589.2

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