發(fā)布時(shí)間：2018-05-09 04:15

  本文選題：苯溴馬隆片 + 別嘌醇片��； 參考：《中國(guó)臨床藥理學(xué)雜志》2017年19期

【摘要】：目的比較苯溴馬隆與別嘌醇對(duì)急性腦梗死合并高尿酸血癥患者的臨床療效和安全性。方法將180例急性腦梗死并且合并高尿酸血癥患者隨機(jī)分為對(duì)照組60例,試驗(yàn)A組60例,試驗(yàn)B組60例,3組患者均給予腦梗死常規(guī)治療。對(duì)照組給予安慰劑(淀粉膠囊)25 mg,qd,口服。試驗(yàn)A組給予別嘌醇100mg,bid,口服。試驗(yàn)B組給予苯溴馬隆50 mg,qd,口服。3組患者均治療14 d。觀察3組患者的臨床療效,血尿酸(UA)、超敏C反應(yīng)蛋白(hs-CRP)、白細(xì)胞介素-6(IL-6)、頸動(dòng)脈內(nèi)膜中膜厚度(IMT)的變化以及藥物不良反應(yīng)的發(fā)生情況。結(jié)果治療后,試驗(yàn)A組、試驗(yàn)B組和對(duì)照組的總有效率分別為88.33%(53/60例),95.00%(57/60例)和76.67%(46/60例),試驗(yàn)A、B組分別與對(duì)照組比較,差異均有統(tǒng)計(jì)學(xué)意義(均P0.05),且試驗(yàn)A組和試驗(yàn)B組比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。治療后,試驗(yàn)A組、試驗(yàn)B組和對(duì)照組的UA值分別為(237.31±10.63),(162.67±10.12),(586.52±50.60)μmol·L-1;hs-CRP分別為(4.93±0.68),(3.57±1.03),(12.07±0.54)mg·L-1;IL-6分別為(78.31±10.63),(68.67±10.12),(190.52±50.60)pg·m L-1;IMT分別為(1.08±0.25),(0.76±0.29),(1.42±0.54)mm,差異均有統(tǒng)計(jì)學(xué)意義(均P0.05)。試驗(yàn)B組的UA、hs-CRP、IL-6及IMT值較試驗(yàn)A組下降更為明顯,差異均有統(tǒng)計(jì)學(xué)意義(均P0.05)。3組患者均未發(fā)生明顯的藥物不良反應(yīng)。結(jié)論苯溴馬隆與別嘌醇均能夠有效降低急性腦梗死合并高尿酸血癥患者的尿酸水平,減輕機(jī)體的炎癥反應(yīng),有效改善動(dòng)脈粥樣硬化的程度,且安全性高,但苯溴馬隆的治療效果更為顯著。
[Abstract]:Objective to compare the clinical efficacy and safety of benzene bromide Malone and allopurinol in patients with acute cerebral infarction with hyperuricemia. Methods 180 patients with acute cerebral infarction and hyperuricemia were randomly divided into 60 cases of control group, 60 cases in group A, 60 cases in group B, and 3 groups of patients given cerebral infarction routine treatment. The control group was given placebo (the placebo group). Starch capsules) 25 mg, QD, orally. Group A was given allopurinol 100mg, bid, oral administration. Group B was given benzene bromine Malone 50 mg, QD, and oral.3 group patients were treated with 14 d. to observe the clinical efficacy of 3 groups of patients, blood uric acid (UA), hypersensitivity C reactive protein, carotid intima membrane thickness and adverse drug reaction Results after treatment, the total effective rate of test A group, test group B and control group were 88.33% (53/60 cases), 95% (57/60 cases) and 76.67% (46/60 cases), test A, and B group compared with control group respectively, the difference was statistically significant (P0.05), and the difference was statistically significant (P0.05) compared with the experimental A group and the test B group. After treatment, test In group A, the UA values in group B and control group were (237.31 + 10.63), (162.67 + 10.12) and (586.52 + 50.60) Mu mol. L-1; hs-CRP was (4.93 + 0.68), (3.57 + 1.03), (12.07 + 0.54) mg. L-1, IL-6 (78.31 + 10.63), PG. M L-1, respectively. There were statistical significance (all P0.05). The values of UA, hs-CRP, IL-6 and IMT in group B were more obvious than those in the experimental A group. The difference was statistically significant (all P0.05) group.3 patients had no obvious adverse drug reactions. Conclusion benzene bromide Malone and allopurinol can effectively reduce the level of uric acid in patients with acute cerebral infarction and hyperuricemia, and reduce the level of uric acid in patients with acute cerebral infarction and hyperuricemia. The inflammatory reaction of light body can effectively improve the degree of atherosclerosis, and its safety is high, but the effect of benzbromine Malone is more significant.

【作者單位】： 武漢市第三醫(yī)院神經(jīng)內(nèi)科;
【分類(lèi)號(hào)】：R589.7;R743.33

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